摘要
目的:研究人免疫缺陷病毒阳性[HIV(+)]非特异性慢性结肠炎腹泻患者结肠黏膜血管和结肠黏膜病理改变.方法:将同期不同症状和病因32例HIV(+)非特异性慢性结肠炎腹泻患者600张电子结肠镜照片与300例非HIV患者3000张结肠镜照片对比,并对32例HIV(+)非特异性慢性结肠炎腹泻患者病理切片内固有层内毛细血管分布情况和黏膜内出血情况进行分析.结果:HIV(+)非特异性慢性结肠炎腹泻患者9例结肠镜照片显示结肠黏膜血管末梢呈环形改变,直径在1-2mm左右,出血后环圈加粗变大;其他3000张肠镜对照照片未发现同样血管改变.HIV(+)非特异性慢性结肠炎腹泻患者32例结肠黏膜病理切片除见非特异性慢性炎症改变外,13例黏膜皮下固有层中有出血,大量红细胞聚集,27例黏膜内皮下固有层中毛细血管明显增生.结论:结肠黏膜血管末梢环形改变可能是HIV(+)非特异性慢性结肠炎腹泻患者结肠黏膜一种特异性特征.
AIM： To observe the pathological changes of colonic mucosal end-artery in human immunodeficiency virus-positive [HW（＋）] patients with nonspecific colitis-caused chronic diarrhea.
METHODS： Colonoscopic pictures from 300 HIV-negative patients （3000 pictures in total） and 32 HIV（＋） patients （600 pictures in total） with chronic diarrhea due to nonspecific colitis were comparatively analyzed. The pathological sections from the 32 HIV（＋） patients were observed for analyses of capillary vessel distributions and mucosal bleedings in lamina propria.
RESULTS： The pictures from 9 HIV（＋） patients with nonspecific colitis-caused chronic diarrhea showed ring-like changes of colonic mucosal end-artery with diameters of 1 to 2 mm, which became larger after bleeding. The same changes were not found in the 3000 pictures from the HIV-negative patients. In addition to chronic non-specific inflammation, mucosal bleeding and conglomeration of red blood cells in lamina propria were observed in the pathological sections of mucosal tissue from 13 HW（＋） patients, and mucosal vascular proliferation in lamina propria was found in 27 HW（＋） patients.
CONCLUSION： The ring-like change of colonic mucosal end-artery may be a special sign in HIV（＋） patients with chronic diarrhea due to nonspecific colitis.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第14期1530-1534,共5页
World Chinese Journal of Digestology
基金
国家973基金资助项目
No.2006CB504201~~
关键词
人免疫缺陷病毒
结肠黏膜血管末梢环形改变
结肠黏膜
慢性腹泻
Human immunodeflciency virus
Ringlike change of colonic mucosal end-artery
Colonicmucosa
Chronic diarrhea
