摘要
花生四烯酸(arachidonic acid,AA)是人体一种必需脂肪酸,该脂肪酸含有20个碳原子,4个双键,是5,8,11,14-二十碳四烯酸.其代谢有两条途径:环氧化酶(COX)和脂氧合酶(LOX).研究表明其代谢限速酶COX和LOX在胰腺癌中呈高表达,AA代谢产物抑制COX和LOX通路,具有抑制肿瘤生长,促进肿瘤细胞凋亡,抑制肿瘤细胞转移等功能.非选择性和选择性COX或LOX抑制剂被用来尝试治疗胰腺及其他肿瘤.
Arachidonic acid （AA）, one of the essential fatty acids, refers to icosa-5, 8, 11, 14-tetraenoic acid constituting 20 carbon atoms and 4 double bonds. There are two major pathways including the lipoxygenase （LOX） pathway to hydroxy derivatives and leukotrienes and the cyclooxygenase （COX） pathway to prostaglandins. Members of the AA metabolizing enzymes have been reported to play a significant role in carcinogenesis, because the modulation of these pathways results in suppression of tumor growth. The both pathways were reported recently to be important in the growth regulation of human pancreatic cancer cells, and COX and LOX metabolic pathways are emerging as key regulators of cell proliferation and neo-angiogenesis. COX and LOX inhibitors are being investigated as potential anticancer drugs and results from clinical trials seem to be encouraging.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第14期1483-1486,共4页
World Chinese Journal of Digestology
基金
江苏省自然科学基金资助项目
No.BK2004049
江苏省卫生厅重大课题资助项目
No.K200602~~
关键词
花生四烯酸
胰腺癌
环氧化酶
脂氧合酶
Arachidonic aci
Pancreatic cancer
Cyclooxygenas
Lipoxygenase
