摘要
目的探讨腹主动脉瘤的发病机理及治疗进展。方法复习近几年有关腹主动脉瘤的发病机理及治疗的文献,进行综述。结果腹主动脉瘤的形成是遗传、解剖、环境、生物化学等多因素相互影响和共同作用的结果。腹主动脉中层细胞外基质的代谢失衡在腹主动脉瘤的形成中起主要作用,而基质金属蛋白酶的活性增加和弹性蛋白与胶原蛋白的基因表达失衡可能是主要原因。腹主动脉瘤的治疗包括外科和内科治疗,内科治疗还处于探索和研究阶段。结论腹主动脉瘤的形成是多因素共同作用的结果,内科治疗是外科治疗的重要补充。
Objective To investigate pathogenesis and therapeutic prospect of abdominal aortic aneurysm （AAA）. Methods Relevant literatures about pathogenesis and ways of treatment for AAA in recent years were reviewed. Results The formation of AAA are associated with heredity, anatomy, environment and biochemistry and other factors. All factors influence and interact with each other. The metabolic disequilibrium of aortic intermediate extracellular matrix plays an important role in the pathogenesis of AAA. The main reasons for the formation of AAA may be the increase of activity of matrix metalloproteinases and the disequilibrium of genetic expressions of elastin and collagen. The therapy of AAA includes surgical and medical treatment. The methods of medical treatment are still in the process of exploration and research. Conclusion The formation of AAA is a synergistical result of multiple factors, and medical treatment is an important supplement of surgical treatment.
出处
《中国普外基础与临床杂志》
CAS
2008年第6期422-425,共4页
Chinese Journal of Bases and Clinics In General Surgery
关键词
腹主动脉瘤
细胞外基质
基质金属蛋白酶
治疗
Abdominal aortic aneurysm Extracellular matrix Matrix metalloproteinases Treatment
