摘要
目的:探讨并评价血、尿透明质酸的测定在肾癌、肾盂癌鉴别诊断中的价值。方法:采集41份血液和尿液样本,其中肾癌17例,肾盂癌14例,正常人10例;采用酶联免疫法(ELISA)测定尿液和血液样本中透明质酸的浓度;采用化学发光法测定尿液中蛋白浓度,用SPSS 11.0分析血液、校正尿液的透明质酸浓度及其比值。结果:在41份血液样本中,各组数据间差异无统计学意义;41份尿液样本中,比较经尿蛋白浓度校正后的尿透明质酸浓度,肾癌组与肾盂癌组差异有统计学意义(P<0.01);比较41例样本的血尿透明质酸浓度比值,肾癌组与肾盂癌组差异有统计学意义(P<0.01)。结论:肾盂癌患者尿液中校正透明质酸浓度明显高于正常人和肾癌患者。尿液透明质酸浓度可作为移行细胞癌的肿瘤标志物,用于肾盂癌的诊断及其与肾癌的鉴别诊断。
Objective To research the usage of hyaluronic acid test in the differential diagnosis between renal cell carcinoma and renal transitional cell carcinoma. Methods Forty-one cases were taken both urine and blood samples, in which there were 17 cases of renal cell carcinoma, 14 cases of renal transitional carcinoma and 10 cases of normal persons. ELISA was used to test hyaluronic acid in urine and blood samples and chemoluminescence immunoassay was used to test the protein in urine samples. The urine protein was used to adjust the hyaluronic acid in urine samples. SPSS 11.0 for windows was used to analyze the data. Results In 41 cases of blood samples, there were no statistic differences among each group;In 41 cases of urine samples, considering the hyaluronic acid concentrations which were adjusted by urine protein, there were statistic difference between transitional cell carcinoma group and renal cell carcinoma group （P 〈 0. 01 ）; The value and blood hyaluronic acid /urine hyaluronic acid after adjustment, showed obviously difference between transitional cell carcinoma group and renal cell carcinoma group（P〈0.01）. Conclusion Hyaluronic acid in urine samples of renal transitional cancer is obviously higher than that in the urine of renal cell carcinoma patients and normal persons. Hyaluronic acid is a good urine tumor marker for transitional cell carcinoma, and can be used to make diagnosis of transitional cell carcinoma and its differential diagnosis with renal cell carcinoma.
出处
《实用诊断与治疗杂志》
2008年第6期431-433,共3页
Journal of Practical Diagnosis and Therapy
关键词
肾细胞癌
透明质酸
肿瘤标志物
Renal cell carcinoma
hyaluronic acid
tumor marker.
