摘要
近年来研究发现，肺功能正常的吸烟者已出现肺血管功能的异常及结构改变。电镜下可观察到内皮细胞的细胞器损伤及功能异常，血管内膜增厚，肺血管肌化；血管周围炎症反应等。这些改变与肺动脉高压的发生密切相关，而吸烟和炎症可能为其重要的影响因素。其理论的深入研究及阐明，对早期防治慢性阻塞性肺疾病的肺动脉重建有重要意义。
Recent studies have found that there have been abnormal pulmonary vascular function and changes in the structure of normal lung function smokers. By electron microscope, we can observe that the injury and dysfunction of the endothelial cells,as well as the thickening of intima, proliferation of collagen matrix, perivascular inflammatory reaction. These changes are closely related to pulmonary hypertension,and probabily smoking and inflammatory are the two vital influencing factors. The in-depth study of these theories will be a great significance for early prevention and treatment of chronic obstructive pulmonary disease and pulmonary artery reconstruction.
出处
《国际呼吸杂志》
2008年第11期663-666,共4页
International Journal of Respiration
基金
广西医疗卫生重点资助项目（200401）
广西青年科学基金资助项目（0728056）
关键词
慢性阻塞性肺疾病
肺血管
非低氧时期
超微结构
Chronic obstructive pulmonary disease
Pulmonary vascular
Non-hypoxic period
Ultrastructural
