摘要
通过7例胰十二指肠切除术后患者胰管内置管获得的纯胰液，用高效液相色谱法测定环丙沙星和头孢哌酮在血清及胰液中的浓度。结果显示：环丙沙星和头孢哌酮的平均胰液渗透率分别为43％和16％，两药在胰液中的浓度均在大多数胰腺感染致病菌的MIC－90以上。
Major pancrestic infection is responsible for more than 80% of deaths in patients with acute pancre-atitis.Therefore,the role of antibiotics in the prevention and treatment of secondary pancreatic infection is important.The choice of antbiotics must be based upon the ability of the antibiotic to penetrate the blood-pancreas banier and toexceed the therapeutic concentration in pancreas for the common pathogens. The penetration of ciprofoxacin and cefop-erazone into Pancreatic juice was investigated in seven patients undergone panreatoduodenectomy. The pancreatic juicewas temporarily diverted to the exterior via a pancreatic duct catheter.This permit the studys of pur pancreatic jnice.the antibiotic concentrations were determined by high-performance liquid chromtography. The concentration ofciprofloxacin and cefoperazone in pancreatic juice were 43% and 16%, respectively,of those in serum, which exceed-ed the concentaion in vitro (MlC-90)for most bacteria associated with pamcreatic infections.
关键词
环丙沙星
头孢哌酮
胰液
渗透率
胰腺炎
治疗
Ciprofloxacine, Cefoperazone, Pancreatic juice ,Penetration rate
