摘要
扫描近场光学显微镜在光学显微镜中具有独特的性能,其突破衍射光限制,具有单分子探测灵敏度,且在研究时不损伤生物样品。文中简要介绍了扫描近场光学显微镜的原理,详述近年来扫描近场光学显微镜在单分子探测中的应用,介绍了扫描近场光学显微镜结合量子点对单分子探测的进展,并对单分子探测的前景做了展望。
Scanning near-field optical:microscope (SNOM) has unique properties in the field of optical microscope. It breaks through optical diffraction limit, having single molecules detection(SMD) sensitivity without injurying biological samples. This article describes the basic principles of SNOM. Recent advances of SNOM in SMD and applications of SNOM combined with quantum dots(QDs) are introduced. The future prospectives of SMD are also presented.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2008年第6期984-988,共5页
Progress in Chemistry
基金
国家自然科学基金项目(No60578025)
国家自然科学基金资助对外交流与合作项目(No30540420311)资助
关键词
扫描近场光学显微镜
单分子探测
量子点
scanning near-field optical microscope(SNOM)
single molecule detection(SMD)
quantum dots