摘要
为了解淋球菌对壮观霉素的敏感性，我们对近８年来由１０个城市性病门诊患者分离的１６３１株淋球菌进行了壮观霉素体外敏感性试验。以琼脂稀释法测定壮观霉素的最小抑菌浓度（ＭＩＣ）。壮观霉素ＭＩＣ范围为２～＞１２８ｍｇ／Ｌ。ＭＩＣ５０和ＭＩＣ９０分别为１６ｍｇ／Ｌ和３２ｍｇ／Ｌ。１６３１株淋球菌中有１６２２株（９９．４５％）对壮观霉素敏感，ＭＩＣ达１２８ｍｇ／Ｌ的耐药菌株仅占０．５５％。研究表明，壮观霉素作为治疗淋病的一线药物对我国目前流行的淋球菌分离株仍相当有效。
The aim of this study was to investigate in vitro antimicrobial susceptibility of Neisseria gonorrhoeae to spectinomycin.1631 strains of Neisseria gonorrhoeae isolated from STD clinical attenders in ten cities over eight years were tested.The minimun inhibitory concentrations(MIC) of spectinomycin were determined by agar dilution method.MIC for spectinomycin ranged from 2mg/L to over 128mg/L.Among 1631 strains,1622 (99 45%)were sensitive to spectinomycin.Only 0.55% of the isolates were resistant,with MIC up to 128mg/L.The study showed that spectinomycin as first line therapy for gonorrhea was still active against contemporary gonococcal isolates in China.
出处
《中国性病艾滋病防治》
1997年第6期267-269,共3页
Chinese Journal of Std & Aids Prevention and Control
关键词
淋球菌
药物敏感性
壮观霉素
药理
Neisseria gonorrhoeae
Antibiotic susceptibility
Spectinomycin
