摘要
目的探讨孕妇和非孕妇体内铁、锌状态与镉水平及其毒作用间的相关性。方法对98名孕妇和73名非孕妇分别测定血镉(BCd)、血清铁(SFe)、血清锌(SZn)、血红蛋白(Hb)、血清铁蛋白(SF)、尿镉(UCd)、尿金属硫蛋白(UMt)、尿β2-微球蛋白(Uβ2-MG)、N-乙酰-β-D-氨基葡萄糖苷酶(UNAG),并进行相关分析。结果孕妇组SZn、Hb、SF含量均明显低于非孕妇组,而UCd、BCd、UMt、Uβ2-MG、UNAG、低SZn率、贫血率均高于非孕妇组;分血组BCd、UCd、UMt、Uβ2-MG、UNAG均高于非贫血组;UNAG、Uβ2-MG随血锌增加而降低;孕妇组镉毒效应随尿镉增高而升高;Hb与UCd、BCd、Uβ2-MG和UMt呈负相关;SF与UCd呈负相关;SZn与UNAG、UMt、Uβ2-MG呈负相关。结论缺铁能促进镉吸收,使镉进入体内的量增加;锌对镉引起的肾损伤有拮抗作用。
Objective To investigate the correlation between ferrum and zinc status and toxic effects of cadmium in pregnant women. Methods BCd, SFe, SZn, Hb, SF, UCd, UMt, Uβ2- MG and UNAG in the blood, serum or urine were measured in 98 pregnant women and 73 non - pregnant women. Correlation analysis was carried out. Results The contents of SZn, Hb and SF were lower, but the contents of UCd, BCd, UMt, Uβ2- MG, UNAG, percentage of anemia and low SZn in the pregnant women were higher than that in non - pregnant women. The contents of BCd, UCd, UMt, Uβ2 - MG and UN- AG were higher in anemia group than that in non - anemia group. With the increase of SZn content, UNAG and Uβ2 - MG decreased and toxic effect of Cd increased with the increase of UCd content, fib was negatively correlated with UCd, BCd, Uβ2 - MG and UMt. SF was negatively correlated with UCd. Meanwhile, SZn was negatively correlated with UNAG, UMt and U^2 - MG. Conclusion Ferrum deficiency can promote the absorption of cadmium, and zinc can antagonize the injury caused by cadmium in kidney.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2008年第6期641-643,共3页
Chinese Journal of Public Health
基金
教育部科研基金项目(2004130)
关键词
铁
锌
镉
孕妇
拮抗作用
ferrum
zinc
cadmium
pregnant women
antagonism
