摘要
目的:观察地氯雷他定治疗季节性变应性鼻炎(AR)的效果及对患者生活质量的影响。方法:进行随机、双盲、有效剂和安慰剂的平行对照研究,利用AR生活质量表即RQLQ对患者进行随访调查。纳入研究的季节性AR患者50例,随机分为3组:A组,给予地氯雷他定口服加生理盐水喷雾;B组,即安慰剂组,安慰剂口服加生理盐水喷雾;C组,即联合组,地氯雷他定口服加内舒拿喷雾。治疗观察2周,患者需要逐日记录其症状的变化。结果:治疗1周和2周后,与B组比较,A组和C组症状明显改善,生活质量明显提高(均P<0.05);C组在改善症状和提高生活质量方面优于A组;B组未见明显改善。结论:地氯雷他定能明显改善季节性AR患者的喷嚏、清涕、鼻塞、鼻痒等症状,提高生活质量。抗组胺药联合鼻内激素比单独应用抗组胺药效果明显。RQLQ问卷调查能对AR患者的生活质量进行有效全面的评估。
Objective：To assess the effect of desloratadine on quality of life （QOL） in patients with seasonal allergic rhinitis. Method：A randomized, double blind, placebo controlled study was designed on fifty patients with seasonal allergic rhinitis. The patients were randomly divided into three groups： A group： taking desloratadine by mouth and taking spraying of normal sodium; B group： placebo group, taking placebo by mouth and taking spraying of normal sodium; C group： taking desloratadine by mouth and taking spraying of Nasonex. Rhinitis quality of life （RQOL） questionnaire was used to evaluate QOL of patients with seasonal allergic rhinitis. The method of taking tabella was one tablet, one time a day; the method of taking spraying was one spray each nostril, once a day. The investigation lasted for two weeks. The RQOL questionnaire was administered at the start of the treatment and after one and two weeks of treatment by the telephone follow-up investigation. Result： After I and 2 weeks of treatment, symptoms scores were significantly decreased in the A group and C group compared with the placebo group （P〈0.05）. After 1 and 2 weeks of treatment by the methods of A and C, the QOL of patients with seasonal allergic rhinitis was significantly improved compared with placebo group （P〈0.05）. There was no QOL improvement in the placebo group. Conclusion：Desloratadine could decrease symptom scores and improve QOL in patients with seasonal allergic rhinitis. The RQOL questionnaire could help doctor to effectively evaluate QOL in patients with seasonal allergic rhinitis, because of its integrity and convenience.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2008年第10期439-442,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
