胰高血糖素样-1及其类似物与糖尿病治疗
摘要
胰高血糖素样肽-1(glucagons-1ike peptide-1,GLP-1)是一种典型的脑-肠轴激素,在中枢由孤束核、背侧及腹侧髓质、嗅球的神经元核周体产生;在外周由分布于空肠、回肠和盲肠的神经内分泌L-细胞分泌,在体内以多种形式存在。人体进餐或口服葡萄糖后,L-细胞被激活,导致GLP-1被迅速释放入血液中,加强胰岛素的合成与分泌。
出处
《中华全科医师杂志》
2008年第6期391-392,共2页
Chinese Journal of General Practitioners
参考文献11
-
1Vilsboll T. On the role of the incretin hormones GIP and GLP-1 in the pathogcncsls of type 2 diabetes mellitus. Dan Mcd Bull, 2004, 51:364-370. 被引量:1
-
2Scheen AJ. Glucagon-like peptide-1 ( GLP-1 ), new target for the treatment of type 2 diabetes. Rev Med Liege, 2007, 62:217-221. 被引量:1
-
3Farilla L, Hui H, Bertolotto C, et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology, 2002, 143:4397-4408. 被引量:1
-
4Preitner F, Ibberson M, Frankin I, et al. Glueo-ineretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. Clin Invest, 2004,113:635-645. 被引量:1
-
5Li Y, Hansotia T, Yusta B, et al. Glucagon-hke peptide-1 receptor signaling modulates beta cell apoptosis. Biol Chem, 2003,278 -471-478. 被引量:1
-
6Doyle ME, Egan JM. Mechanisms of action of glueagon-like peptide-1 in pancreas. Pharmaeol Theraphy, 2007, 113:546-593. 被引量:1
-
7Farilla L, Bulotta A, Hirshberg B, et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology, 2003, 144: 5149-5158. 被引量:1
-
8Fineman MS, Bicsak TA, Shen LZ, et al. Effect on glycemic control of exenatide ( synthetic exendin-4 ) additive to existing mefformin and/or sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care, 2003, 26:2370-2377. 被引量:1
-
9Rolin B, Larsen MO, Goffredsen CF, et al. The long-acting GLP-1 derivative NN2211 ameliorates glycelnia increases beta-cell mass in diabetic mice. Physiol Endocrinol Metab, 2002, 283: 745 -752. 被引量:1
-
10Madsbad S, Schmitz O, Ranstam J, et al. Improved glycemic contrel with no weight increase in patients with type 2 diabetes after once-daffy treatment with the long-acting glucagort-like peptide 1 analog liraglutide( NN2211 ) . Diabetes Care, 2004, 27 : 1335-1342. 被引量:1
-
1余国膺.用个体-特异的多能干细胞模型治疗长QT综合征[J].中国心脏起搏与心电生理杂志,2011,25(3):233-233.
-
2缪希莉,梅四清,黄新次.急性心肌梗死后患者不同时相血清炎性细胞因子水平的变化[J].微循环学杂志,2008,18(4):68-69. 被引量:5
-
3侯景玉.心型脂肪酸结合蛋白与急性心肌梗死预后的关系[J].中国老年学杂志,2014,34(24):7084-7085. 被引量:2
-
4邬磊,潘炜滨.利拉鲁肽治疗2型糖尿病的临床疗效观察[J].中外医学研究,2014,12(10):30-31. 被引量:2
-
5热休克蛋白70可能是急性心肌梗死又一标志物[J].基础医学与临床,2005,25(4):374-374.
-
6王丽茹.GLP-1类似物治疗糖尿病的研究进展[J].中国煤炭工业医学杂志,2011,14(1):141-142. 被引量:2
-
7李经.胰岛素治疗中该如何加餐[J].糖尿病之友,2007(8):41-41.
-
8刘璐,戴如春.GLP-1对骨骼、中枢神经系统的影响及其机制研究进展[J].中华内分泌代谢杂志,2016,32(6):527-530. 被引量:1
-
9易湘,鲁艳菊,付娟,韦星.GLP-1抗心肌缺血再灌注损伤分子机制的研究进展[J].中国动脉硬化杂志,2015,23(5):532-535. 被引量:1
-
10苏文坚.血清心肌肌钙蛋白I对判断非ST段抬高急性冠状动脉综合征近期预后的价值[J].临床荟萃,2004,19(11):641-642. 被引量:2