摘要
学术背景:虽然已经有应用组织工程骨修复颅颌面骨缺损的报道,但因其缺乏植入早期的力学强度,尚不能应用在四肢负重部位修复骨缺损。目的:探讨负重组织工程骨的新型支架的仿生力学设计、多孔纯镁支架的仿生形态学设计和多孔纯镁支架仿人骨材料表面涂层的仿生技术,以及其他负重组织工程骨候选支架仿生技术和外科人工金属植入物仿生表面涂层技术的发展现状。检索策略:应用计算机检索EI数据库1899/2007与仿生材料相关的文献,并以ELSERVIER、Springer、万方外文文献数据库以及CHKI中文数据库文献索引为辅助,英文检索词"Biomimetic materials",中文检索词"仿生学"。纳入与仿生学、仿生力学、仿生材料及技术相关的文章。文献评价:共得到3501个索引,选择35篇完全符合标准的文献进行综述。其中有关仿生学1篇,生物力学1篇,组织工程用仿生材料1篇,负重组织工程骨的新型支架3篇,医学用金属材料的仿生表面涂层技术12篇,医学用生物陶瓷的仿生表面涂层技术1篇,医学用生物高分子聚合物的仿生涂层技术4篇,纳米生物有机物大分子和生物无机物分子的自组装6篇,生物材料的体积修饰或改性2篇。资料综合:①为解决负重组织工程骨早期力学强度不足问题,仿生涂层的多孔纯镁新型支架是临床试用前期研究最佳候选方案,仿生涂层的多孔纯钛支架,可能作为上述研究的其他选择。②多孔双相生物陶瓷支架压缩强度较低,可能不足以解决问题,利用仿生技术对整体修饰或改性可能是有前景的。③多孔生物高分子聚合物支架,可以利用仿生技术对整体修饰或改性以改善力学性能,但是效果非常有限。结论:到目前为止还不能解决负重组织工程骨的早期力学性能不足问题。外科植入物金属,以及多孔生物金属、生物陶瓷、生物高分子聚合物等组织工程骨支架表面,均可利�
BACKGROUND： Although the application of tissue engineering bones to repair bone defects of cranio-maxillofacial has been reported, there are no applications for repairing bone defects of loaded four limbs for lack of mechanical strength in early period of implanting. OBJECTIVE： To investigate the biomimetic mechanics design of new type of scaffolds for loaded tissue engineering bones, the biomimetic morphological design of porous pure magnesium scaffolds, and biomimetic bone-like coating technology for porous pure magnesium bone-like scaffolds. The biomimetic techniques progress of other candidates for scaffolds of loaded tissue engineering bones and biomimetic coating technology for metallic surgery implants were also given. RETRIEVAL STRATEGY： A computer-based search for the literatures concerning biomimetic materials was undertaken in EI databases from 1899 to 2007, with the aid of ELSERVIER, Springer, Wanfang foreign language databases and CHKI Chinese databases. The English keywords were ＂biomimetic materials＂, and the Chinese ones were ＂biomimetics＂. Literatures concerning biomimetics, biomimetic mechanics, biomimetic materials and biomimetic techniques were collected. LITERATURE EVALUATION： Among 3 501 obtained indexes, 35 concerning inclusion criteria were selected for summarized. One paper concerning bionics or biomimetics; one paper, biomechanics; one paper, biomimetic materials for tissue engineering; three papers, new scaffolds for loaded tissue engineering bones; twelve papers, biomimetic coating techniques for medical metal materials; one paper, biomimetic coating techniques for medical bio-ceramics; four papers, biomimetic coating techniques for medical bio-polymers; six papers, self-assembly between organic nano-bio-macromolecules and inorganic nano-bio-compounds; two papers, bulk modification of biomaterials. DATA SYNTHESIS： （1）New type of porous pure magnesium scaffolds with bone-like biomimetic coating is the best candidate of pre-research for clinical application to solve
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第14期2721-2726,共6页
Journal of Clinical Rehabilitative Tissue Engineering Research
