摘要
目的:探讨血清中CYFRA21-1、CA125和NSE三种肿瘤标志物在不同组织类型肺癌中的临床诊断价值。方法:采用电化学发光免疫分析(ECLIA)技术测定82例肺癌患者、16例肺良性疾病患者、40例健康人血清中的CYFRA21-1、CA125和NSE水平。结果:肺癌组的三种肿瘤标志物水平均高于肺良性疾病组和正常对照组(P<0.05)。其中血清中CYFRA21-1、CA125、NSE的敏感性分别为61.0%、51.2%、34.1%,三者联合检测的敏感性为85.4%。CYFRA21-1在鳞癌的敏感性最高为78.6%;CA125在腺癌的敏感性为75%;NSE在小细胞未分化癌敏感性最高为66.7%。结论:血清CYFRA21-1、CA125和NSE的检测,尤其是三项联合检测有助于临床对肺癌的诊断,并对组织分型有较高的参考价值。
Objective ：To explore the clinical diagnostic value of three tumor markers CYFRA21 - 1 , CA125 and NSE in lung cancer with different histological types. Methods：The electro chemiluminesence immunoassay was adopted to dectect CYFRA21 -1 ,CA125 and NSE in the serum of 82 patieats with lung cancer ,16 patieats with benign diseases and 40 health persons. Results ：The levels of three tumor makers in lung cancer group were higher than those in the groups of benign diseases and health persons. The sensitivities of CYFRA21 - 1, CA125 and NSE were 61.0% ,51.2% ,34.1% ,respectively. The sensitivity for combined detection was 85.4%. The highest sensitivity of CYFRA 21 - 1 for squamous cell carcinoma was 78.6%, CA125 for adenocarcinoma 75% , NSE for undifferentiated small cell cancer 66.7%. Conclusion： CYFRA21 - 1 CA125 ,and NSE are useful for the diagnosis of the lung cancer and histological type , especially combining detection of three serum tumor markers.
出处
《现代肿瘤医学》
CAS
2008年第6期951-953,共3页
Journal of Modern Oncology
