摘要
目的探讨灯盏花素注射液对妊娠大鼠血清胰岛素样生长因子-Ⅱ（IGF-Ⅱ）浓度及胎鼠体重、身长、体重系数变化的影响。方法利用放射免疫法测定大鼠及胎鼠血清中IGF-Ⅱ的浓度，并测定胎鼠的体重、身长，计算体重系数。结果①3组大鼠血清IGF—Ⅱ浓度相近；胎儿生长受限（FGR）组的胎鼠血清IGF—Ⅱ浓度低于正常对照组（P〈0．05），干预组IGF-Ⅱ浓度高于FGR组。②胎鼠体重、身长：正常对照组〉FGR＋干预组FGR组，各组相比均有显著性差异（P〈0．05）。③胎鼠体重系数正常对照组FGR＋干预组FGR组，正常对照组与其余两组相比有统计学意义（P〈0．05）。结论①大鼠、胎鼠血清中IGF—Ⅱ的来源不同，不能通过胎盘屏障交换；②检测母血中IGF-Ⅱ的浓度不能用以诊断FGR．③胎血IGF-Ⅱ浓度下降可能是导致FGR的重要原因。④灯盏花素可有效治疗和保护胎鼠胎儿生长。
Objective To discuss the influence of Breviscapine Injection on concentration of serum IGF-Ⅱ in pregnant rats and changes of fetus rat body weight, body length, and body-mass index. Methods Radio-immunity was used to determine the concentration of serum IGF-Ⅱ in mother rats and fetus rats. Body weight and body length were surveyed, and body-mass index was calculated. Results ①the serum IGF-Ⅱ concentration of mother rats in three groups were close; the IGF-Ⅱ concentration of fetus rats in the FGR group was lower than the control group （P〈0.05） and IGF-Ⅱ concentration of fetus rats in the intervention group was higher than the FGR group. ②Body weight and body length of fetus rats： the control group〉the FGR＋intervention group〉 the FGR group, and the difference between each group was significant （P〈0.05）. ③Body-mass index： the control group〉the FGR＋intervention group〉 the FGR group, and difference between the control group and the other two groups was significant （P〈0.05）. Conclusion ①Mother rats and fetus rats have different source of IGF-Ⅱ, which can not pass through placental barrier for exchange; ② The detected IGF-Ⅱ concentration of mother rats can not be used to diagnose FGR; ③ The decrease of IGF-Ⅱ concentration of fetus rats may be a key reason leading to FGR; ④ Breviscapine can treat fetal growth retardation effectively.
出处
《国际中医中药杂志》
2008年第3期174-175,181,共3页
International Journal of Traditional Chinese Medicine
