摘要
目的:观察杜仲叶提取物急慢性降压作用。方法:以间接测压法测量清醒大鼠尾动脉血压:(1)测量自发性高血压大鼠(SHR)多次灌胃杜仲叶提取物的血压变化,观察其慢性降压作用。(2)测量肾性高血压大鼠1次灌胃杜仲提取物后1,2,4,6,8h的血压,以观察提取物急性降压作用。结果:(1)连续18d灌胃杜仲叶提取物4.2g.kg-1或6.3g.kg-1均明显降低SHR血压。(2)一次性灌杜仲叶提取物4.2g.kg-1或6.3g.kg-1均明显降低肾性高血压大鼠血压。结论:杜仲叶提取物有明显的降低急慢性血压作用。
OBJECTIVE To investigate the acute and chronic hypotensive effects of eucornrnia bark extract. METHODS The tail artery blood pressure of awake rats were indirectly measured as follows： （ 1 ）The change of blood pressure in SHR given eucommia bark extract many times so that we could investigate it＇s chronic hypotensive effect; （2）We measured blood pressures of renal hypertension rats at 1,2,4,6,8 h after being given eucommia bark extract in order to investigate it＇s acute hypotensive effect. RESULTS （1）eucommia bark extract in the dosage of 4. 2 g·kg^-1 or 6. 3 g·kg^-1 for eighteen days could reduce the blood pressures of SHR obviously. （2）eucommia bark extract in the dosage of 4. 2 g·kg^-1 or 6.3 g·kg^-1 once could reduce the blood pressures of renal hypertension rats obviously. CONCLUSION Eucommia bark extract has obvious acute and chronic hypotensive effects.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2007年第7期901-903,共3页
Chinese Journal of Hospital Pharmacy
关键词
杜仲叶提取物
血压
大鼠
extact of eucommia ulmoides Leaves
blood pressure
rats
