摘要
对３－甲硫基－７－氧代吡唑并（５，４－ｅ）－１，２，４－三嗪的成苷反应进行了研究，当保护基为乙酰基时，生成核苷β－体为主产物，当保护基为苯甲酰基时全部是β一体。端位构型用＾１ＨＮＭＲ确定。在五元环中，顺位质子比反位质子裂分常数大。
The ribonucleosides of pyrazolo (5,4 - e) - 1,2,4 - triazine derivatives were synthesized. The α,β- isomes were distinguished with 1H NMR. β - isomer was the major product in acetyl protected ribonucleosides. In benzoyl protected ribonucleosides, no α- isomer was formed. The JH1H2 of cis isomer was bigger than that of trans in five membered ring.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1997年第3期256-259,共4页
Chinese Journal of Organic Chemistry
关键词
核苷
吡唑并三嗪
甲硫基
合成
pyrazolo(5,4 - e) - 1,2,4 - triazine derivatives , ribonucleosides, synthesis
