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生物素亚适量辨析 被引量:1

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摘要 利用糖质为原料的谷氨酸产生菌绝大多数为生物素营养缺陷型,生物素会影响其细胞的生长、代谢和细胞膜渗透性。所以,控制生物素用量是谷氨酸发酵生产的关键之一。教学过程中,经常遇到学生提问什么是“生物素亚适量”,是“亚适量控制生物素(5~10μg/L)”,还是菌体“
作者 邱立友
出处 《发酵科技通讯》 CAS 1997年第1期17-18,共2页 Bulletin of Fermentation Science and Technology
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同被引文献14

  • 1Kinoshita S,Udaka S,Shimono M. Studies on the amino acid fermentation Part I.Production of L-giutamic acid by various microorganisms[J].Journal of General Microbiology,2004,(06):331-343. 被引量:1
  • 2Shiio I,Otsuka S,Takahashi M. Effect of biotin on the bacterial formation of glutamic acid I.Glutamate formation and cellular permeability of amino acids[J].Journal of Biochemisitry,1962,(01):56-62. 被引量:1
  • 3Clement Y,Laneelle G. Glutamate excretion mechanism in Corynebacterium glutamicum:triggering by biotin starvation or by surfactant addition[J].Journal of General Microbiology,1986,(04):925-929. 被引量:1
  • 4Takinami K,Yoshii H,Tsuri H. Biochemical effects of fatty acid and its derivatives on L-glutamic acid fermentation.Part Ⅲ.Biotin-Tween 60 relationship in the accumulation of L-glutamic acid and the growth of Brevibacterium lactofermentum[J].Agricultural and Biological Chemistry,1965,(01):351-359. 被引量:1
  • 5Nara T,Samejima H,Kinoshita S. Effect of penicillin on amino acid fermentation[J].Agricultural and Biological Chemistry,1964,(01):120-124. 被引量:1
  • 6Nakao Y,Kikuchi M,Suzuki M. Microbial production of glutamic acid by glycerol auxotrophs.Ⅰ.Induction of glycerol auxotrophs and production of L-glutamic acid from nparaffins[J].Agricultural Biology and Chemistry,1972,(03):490-496. 被引量:1
  • 7Kitano K,Sugiyama Y,Kanzaki T. L-Glutamate fermentation with acetic acid by an oleic requiring mutant.Ⅱ.Inhibitory factors against the extracellular accumulation of L-glutamate[J].Journal of Fermentation and Technology,1972,(04):182-191. 被引量:1
  • 8Clement Y,Escoffier B,Trombe MC. Is glutamate excreted by its uptake system in Corynebacterium glutamicum A working hypothesis[J].Journal of General Microbiology,1984,(10):2589-2594. 被引量:1
  • 9Christian H,Reinhard K. Evidence for an efflux carrier system involved in the secretion of glutamate by Corynebacterium glutamicum[J].Archives of Microbiology,1989,(04):342-347. 被引量:1
  • 10Marcella G,Christian H,Reilhard K. Carrier-mediated glutamate secretion by Corynebacterium glutamicum under biotin limitation[J].Biochimica Et Biophysica Acta,1992,(01):115-123. 被引量:1

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