摘要
为了解强心扩血管新药羟苯氨酮（ｏｘｙｐｈｅｎａｍｏｎｅ，９００３）对在体心血管系统的效应，用多导生理仪与电磁流量计测定大鼠，猫与狗的心脏血流动力学参数。结果表明，静注羟苯氨酮引起血压与血管阻力中度下降，心输出量，心肌收缩力与收缩力变化速度，冠状动脉和股动脉血流量明显增加。羟苯氨酮对心率与左室压的影响呈现种系差别，它增加狗的左室收缩压与压力变化速度，降低左室舒张末期压力，小剂量羟苯氨酮（１或３ｍｇ·ｋｇ－１）引起狗的心率轻度降低，剂量增到６ｍｇ·ｋｇ－１，心率中度加快。羟苯氨酮不影响猫的心率与左室压。大鼠静注羟苯氨酮后引起心率，左室收缩压与压力变化速度降低，左室舒张末期压力无变化。羟苯氨酮对心脏血流动力学的影响有待用病理模型作进一步观察。
For studying the cardiotonic and vasaodilating effect of oxyphenamone in vivo , cardiac hemodynamic variables of anesthetized normal rats, cats and dogs were determined with a polygraph and electromagnetic flowmeters. Intravenous injection of oxyphenamone (0 5～10 mg·kg -1 ) dose dependently decreased the mean arterial pressure and systemic vascular resistance moderately and increased cardiac output, myocardial contractile force and ±d T /d t max . The blood flow of coronary and femoral arteries increased markedly and their vascular resistance decreased but the blood flow and vascular resistance of cerebral artery did not change. Some species differences were observed in the effect of oxyphenamone on heart rate (HR) and left ventricular pressure (LVP). Oxyphenamone did not influence the HR and LVP in normal cats. It decreased the HR, left ventricular systolic pressure (LVSP) and ±d P /d t max , while did not affect the left ventricular end diastolic pressure (LVEDP) in rats. In contrast, administration of oxyphenamone to dogs increased LVSP and ±d P /d t max markedly and diminished LVEDP slightly. Oxyphenamone decreased HR slightly at lower dosage (1 and 3 mg·kg -1 ), but increased heart rate moderately at high dose (6 mg·kg -1 ) in dogs. These indicate that oxyphenamone has cardiotonic and vasodilating effects in vivo . Whether the effects of oxyphenamone on cardiac hemodynamics would be useful for the treatment of heart failure should be evaluated further.
出处
《药学学报》
CAS
CSCD
北大核心
1997年第10期744-749,共6页
Acta Pharmaceutica Sinica
基金
国家医药管理局新药研究基金
关键词
强心扩血管药
羟苯氨酮
心脏
血流动力学
Oxyphenamone
Cardiotonic agents
Vasodilator agents
Inodilators
Cardiac hemodynamics
