摘要
观察纳洛酮（ＮＡＬ）用于新生儿窒息复苏的效果，并与碳酸氢钠（ＳＢ）进行比较。４０例产后重度窒息新生儿随机分为两组，每组２０例，分别于出生后立即脐静脉注射ＮＡＬ或ＳＢ，同时通畅呼吸道，进行有效通气。距首次注药后１０ｍｉｎ两组均经静脉重复注药一次。结果：ＮＡＬ组新生儿３ｍｉｎ、５ｍｉｎＡｐｇａｒ评分显著高于ＳＢ组（Ｐ＜０．０１，Ｐ＜０．０５），自主呼吸建立时间亦明显早于ＳＢ组（Ｐ＜０．０１），呼吸频率及心率均较ＳＢ组明显增快（Ｐ＜０．０１），出生后４８ｈＮＡＣＳ评分ＮＡＬ组亦高于ＳＢ组（Ｐ＜０．０５）。结论：ＮＡＬ能有效地缩短新生儿窒息时间。
The effect of naloxone and sodium bicarbonate during resuscitation was compared in 40 asphyxial newborns. Naloxone 0 2 mg was injected via umbilical vein soon after birth and iv at 10min after birth in 20 asphyxial newborns(group I)and 5% sodium bicarbonate 3ml/kg was used instead of naloxone in another 20 asphyxial newborns (group Ⅱ). The results show that Apgar scores at 3 and 5 min in group I were significantly higher than that in group Ⅱ. Spontaneous respiration was established remarkably earlier in group I than that in group Ⅱ. The NACS score at 48h after birth was significantly higher in group Ⅰ than that in group Ⅱ. It is concluded that the time of apnea can be effectively shortened by naloxone and naloxone is a good choice during resuscitation in the asphyxial newborn.
出处
《临床麻醉学杂志》
CAS
CSCD
1997年第4期218-219,共2页
Journal of Clinical Anesthesiology
关键词
纳洛酮
复苏
新生儿窒息
Naloxone Sodium bicarbonate Newborn Resuscitation
