摘要
目的探讨寻常型银屑病与幽门螺杆菌(Hp)感染的相关性,观察抗Hp治疗对寻常型银屑病的临床疗效。方法选取62例寻常型银屑病患者与35例健康体检者,通过尿素13C呼气试验及Hp粪便抗原检测观察患者感染Hp情况,比较两组的检测结果。62例银屑病患者根据Hp感染情况分为治疗组(Hp阳性患者32例)和对照组(Hp阴性患者30例),治疗组给予抗Hp三联(奥美拉唑、阿莫西林、克拉霉素)治疗及外用维甲酸软膏,对照组仅外用维甲酸软膏,观察银屑病面积和严重程度指数评分(PASI)、瘙痒视觉模拟评分(VAS)及治疗总有效率。结果银屑病组Hp感染率为51.6%,健康体检组Hp感染率为22.9%,两组间比较有显著性差异(P<0.05)。治疗组与对照组银屑病患者的治疗总有效率分别为62.5%和36.7%,两组间比较有显著性差异(P<0.05),两组治疗后的PASI、VAS评分亦有显著性差异(P<0.05)。结论寻常型银屑病与Hp感染有关。对于HP感染阳性的寻常型银屑病患者,在治疗银屑病的同时进行抗HP治疗,可以提高对银屑病的疗效。
Objective To explore the relationship between Helicobacter pylori （Hp） infection and psoriasis vulgaris, and investigate the effect of anti-Hp therapy on the patients with psoriasis vulgaris. Methods 13C-urea expiration test and detection of Hp antigen in feces samples were performed to identify Hp infection in 62 psoriasis patients and 35 healthy persons. Detection results of the two groups were statistically analyzed. The 62 psoriasis patients were divided into two groups based on the detection of Hp infection： Hp positive group （32 cases） and Hp negative group （30 cases）. Patients in Hp positive group were given anti-Hp triple therapy （omeprazole, amoxicillin, clarithromycin） for two weeks and topical application of tretinoin for six weeks, while the patients in Hp negative group were treated only with topical use of tretinoin for six weeks. The total effective rate, score of psoriasis area, severity index （PASI） and visual analogue scale （VAS） of pruritus were recorded and then analyzed. Results The Hp infection rate in 62 psoriasis patients was 51.6%, and in healthy individuals was 22.9%, the difference between the two groups was statistically significant （P〈0.05）. Among the psoriasis cases, the total efficacious rates in Hp positive group and Hp negative group were 62.5% and 36.7%, respectively, with a statistically significant difference （P〈0.05）. The significant differences also existed in PASI and VAS scores between two treatment groups （P〈0.05）. Conclusions The results suggest that Hp infection is correlated with psoriasis vulgaris. Anti-Hp therapy may improve the therapeutic effect in the patients with psoriasis combined with Hp infection.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2008年第5期600-602,共3页
Medical Journal of Chinese People's Liberation Army
