摘要
本文观察了氯丙嗪抗实验性心律失常作用。结果显示,氯丙嗪能降低氟仿诱发小鼠室颤率;可对抗Bacl2所致大鼠室性心律失常;可明显提高乌头碱诱发大鼠心律失常用量;可防治肾上腺素诱发家兔产生的心律失常。 大同医专教务处副处长,037008 大同医专药理教研室
chlorpromazine has many pharmacologi cal effects,but the antiarrhythmic effects have never been reported. Th is article reports antiarrhythmic effeccs of chlorprmoaline in animal experiment. Result shows that chlorpromazine can reduce the incidence of ventricular fibrillation caused by chloroforne in mice (P<0. 01)lower incidence of arrhythmica induced by adrenaline in rabbits (P<0. 05),Shorten arrhythmic sustained time induced by Ba-cl2(P<0. 01) .Postpone occurrence of arrhythmic induced by increacing the dose of aconitine (P<0. 01). It's thus clear that chlo.rpromazine have abvious antiarrhythmic effects, The maehanism of antiarrnythmia remains to be reserched farther.
关键词
氯丙嗪
心律失常
chlorpromazim
experimental arrhythmia
