摘要
目的分析代谢综合征(MS)患者合并尿路结石的特点,试图找到MS患者罹患尿路结石的相关危险因素。方法选取MS合并尿路结石患者85例,MS排除结石患者80例作为对照组。测定两组人群血清同型半胱氨酸(Hcy)、血尿酸(SUA)、24小时尿酸(TUA)、空腹和餐后2小时血糖、胰岛素、24小时尿微量白蛋白(TUP)等。以上危险因素为自变量,有无尿路结石为应变量做Logistic多元逐步回归。结果TUA、SUA、胰岛素抵抗指数、Hcy、TUP进入回归模型(R2=0.823,P=0.002)。结论高尿酸排泄、血尿酸水平增高、胰岛素抵抗、血Hcy增高等是MS患者罹患尿路结石的危险因素;降低血尿酸水平、改善胰岛素抵抗对于减少MS尿路结石的发生具有重要意义。
Objective Analyze the characteristics of MS patients comphcated with lithangiuria to find the related risk factors among metabohc syndrome patients with hthangiuria. Methods 85 patients of MS complicated with hthangiuria were selected and 80 cases of MS patients in the same hospital without hthangiuria were selected as the control group. In all patients serum homocysteic acid was determined by HPLC, serum creatinine, BUN, uric acid, 24h hours＇ urine acid, 24 hours＇ urine microalbumin, serum fasting and postprandial glucose was determined by peroxidase method, serum fasting and postprandial insulin was determined by chemical photogenesis method. The mentioned above possible rehted risk factors were classified as variables and Logistic regression was performed to analyze relative risk factors. Results Logistic stepwise regression analysis showed that the determination coefficient R^2 = 0. 823 （ P = 0. 002） and TUA,SUA,IR index,Hcy,TUP entered the model that were considered as the major risk factors. Conclusions High secretion of urine acid, increase of serum urine acid, insulin resistance, increase of serum Hcy and high secretion of urine micro albumin in MS patients predisposed the incidence of lithangiuria and lowering of urine acid and improvement of insulin resistance could decease the incidence of hthangiuria in MS patients.
出处
《临床内科杂志》
CAS
2008年第5期336-338,共3页
Journal of Clinical Internal Medicine
