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脓疡型肺癌的特点及治疗

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摘要 目的 总结分析脓疡型肺癌的特点,探讨有效的治疗方法。方法 脓疡型肺癌患者19例,其中无远处转移者行肺叶或全肺切除加淋巴结清扫术,术后化疗;有远处转移者行肺叶切除,术后化疗,酌情行γ刀治疗;术中未能切除病灶及未手术者,行介入治疗(或化疗),介入方案主要为MCV方案,疗效不佳改顺铂加多西紫衫醇或吉西他宾,或654-2加MCV介入方案。结果 10例无远处血行转移者中,5例行根治性肺叶切除或全肺切除,其中3例于术后19-33个月死于肿瘤复发,2例于术后3年失访;4例行剖胸探查。9例有远处转移的患者中,2例单发脑转移者、2例骨转移者、2例肝直接受侵伴脑转移者行肺叶切除手术,其中5例死于术后11-23个月,1例术后13个月仍在随访中。所有原发病灶切除的患者生活质量明显提高。2例未手术和2例剖胸探查者在用MCV方案介入治疗2次失败后,改用顺铂加多西紫衫醇或吉西他宾方案,病情仍进展,死于严重的呼吸窘迫;另2例剖胸探查和2例未手术者在用MCV方案介入治疗2次,病情加重的情况下,改用654-2加MCV方案介入治疗,气急等症状改善,肿块明显缩小,分别于治疗后7.1-10.3个月死于全身衰竭等因素。结论 手术切除原发病灶是治疗脓疡型肺癌的关键,对于未能切除原发病灶者,普通化疗或介入治疗效果差,微循环介入治疗效果较好。
出处 《上海交通大学学报(医学版)》 CAS CSCD 北大核心 2008年第5期610-611,共2页 Journal of Shanghai Jiao tong University:Medical Science
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