摘要
目的 探讨全脑放疗加分次立体定向放射治疗（FSRT）对非小细胞肺癌（NSCLC）脑转移的疗效。方法 62例NSCLC脑转移患者接受全脑放疗（WBRT）36～40Gy后行FSRT治疗，放疗结束后行脑部CT或MRI评定疗效。结果 全组62例均按计划完成脑部放疗，治疗后全组总有效率为82．3％；52例治疗前有神经系统症状和体征的患者均有不同程度的改善；中位生存期11个月，1年生存率为43．6％。结论 全脑照射加FSRT治疗NSCLC脑转移有较高的局控率，毒副反应轻，值得推广应用。
Objective The aim of this study is to evaluate the therapeutic effect with whole brain radiotherapy （WBRT） and then with fractionated stereotaetic radiotherapy （FSRT） in non-small cell lung cancer （NSCLC） with brain metastasis. Methods A total of 62 NSCLC patients with brain metastasis received FSRT after WBRT to total dose of 36-40 Gy. Response was evaluated by brain CT or MRI after radiotherapy. Results All the patients completed radiotherapy combined with chemotherapy. The objective brain response rate was 82.3%. Symptom relief was observed in all the 52 patients with neurological symptoms. A median survival duration was 11 months. The l-year survival rate was 43.6%. Conclusions WBRT with FSRT is highly effective and well tolerated in treatment of NSCLC with brain metastasis. It may be worthy of further clinical investigation and application.
出处
《肿瘤基础与临床》
2008年第3期236-238,共3页
journal of basic and clinical oncology
关键词
非小细胞肺癌
脑转移
立体定向放射治疗
疗效
non-small cell lung cancer
brain metastasis
fractionated stereotactic radiotherapy
efficacy
