摘要
心房颤动(房颤)是一种常见的心律失常,治疗较困难,临床上一直缺乏理想的治疗方法,目前针对房颤发生基质为靶点的新治疗方法日益受到关注。最近一些临床试验提示血管紧张素转换酶抑制剂(ACEI)和血管紧张素受体拮抗剂(ARB)可在高血压、左室肥厚、充血性心力衰竭、电复律的患者中预防新发房颤的发生和房颤的复发,但这种作用的具体机制还未得到深入的探讨。一些实验性研究提示肾素-血管紧张素系统(RAS)可能在房颤的电重构和结构重构中起重要作用。现对RAS在房颤发生和发展中的作用及可能机制,以及ACEI和ARB在房颤预防中的作用和可能机制作了系统的综述。
Atrial fibrillation (Af) is a common arrhythmia that is difficult to treat. It lacks an ideal general therapy, There is increasing interest in novel therapeutic approaches that target Af-substrate development. Recent trials suggest that angiotensin converting enzyme inhibi- tors (ACEI} and angiotensin receptor blockers (ARB} may be useful,particularly in patients with cases of hypertension and left ventricular hypertrophy, congestive heart failure, and those undergoing electrical cardioversion for Af. The mechanisms of this approach are under investigation. Some experimental studies also show that the renin angiotensin system ( RAS ) is involved in atrial electrophysiological and structural remodelling. This article reviews the role and mechanism of RAS in the pathogenesis of Af,and information pertaining to the clinical use and mechanism of action of ACEI and ARBs in Af.
出处
《心血管病学进展》
CAS
2008年第3期429-432,共4页
Advances in Cardiovascular Diseases
关键词
肾素-血管紧张素系统
心房颤动
电重构
结构重构
renin-angiotensin system
atrial fibrillation
structural remodeling
electrophysiological remodelling