摘要
目的:探讨对各类骨科术后病人应用高乌甲素行自控静脉镇痛(PCIA)的有效性和安全性。方法:60例成年ASAⅠ～Ⅱ行择期骨科手术病人,随机分为两组,曲马多(T)组:曲马多16mg/kg、高乌甲素组(G)组:高乌甲素0.35mg/kg,均用生理盐水稀释至100ml,以2ml/h行PCIA。记录两组在置泵后2、4、8、12、24、48h的视觉模拟评分值(VAS)、病人对镇痛治疗总体印象评分及在各时间段中的不良反应(恶心、呕吐、皮肤瘙痒、嗜睡、心悸)。结果:T组、G组48h内各时间点VAS和PCA结束后镇痛治疗总体印象评分差异无显著性(P>0.05),T组、G组恶心呕吐发生率分别为26.7%、3.3%,G组明显低于T组(P<0.05)。结论:高乌甲素对骨科手术后病人自控镇痛安全,镇痛确切有效,在PCIA期间恶心、呕吐、皮肤瘙痒不良反应较曲马多明显减少。
Objective.To study the analgesic efficiency and safety of patient-controlled intravenous analgesia （PCIA） with lappaeonitine and tramadol in patients undergoing the operation in pantomime-vertebral column region.Methods：Sixty ASA Ⅰ - Ⅱ adult patients undertaken for the operation in pantomine-vertebral column region were divided into two groups randomly,30 cases in each group.The tramadol group （group T） was given tramadol 16 mg/kg,while lappaconitine group （group G） with lappaconitine 0.35 mg/kg,all two kinds of drugs were diluted respectively in normal saline to 100 ml with background flow 2 ml/h,lockout time 15 minutes as well as PCA bolus 0.5 ml.The score value of visual analogue scale （VAS） in 2,4,8,12,24 and 48 hours after the operation,patient＇s evaluation of the analgesic effect of PCA as well as side effects such as nausea and vomiting,dizziness,respiratory depression ,palpitation and so on in different times were observed and recorded respectively.Results：There was no statistically significant difference between two groups in VAS and the patients evaluation of the analgesic effect of PCA in different times（P〉0.05）.The side effects in group G were less than those in group T （P〉0.05）.Conclusion：Using lappaconitine for postoperative patient-controlled analesia in patients undergoing the operation of catagmatic surgery is safe, with a definite analgesic effect, and its side effects such as nausea and vomiting as well as cutaneous those of tramadol,especially nausea and vomiting.
出处
《现代医药卫生》
2008年第11期1601-1602,共2页
Journal of Modern Medicine & Health
关键词
高乌甲素
病人
自控静脉镇痛
Lappaconitine
Patient-controlled intravenous analgesia
