摘要
目的研究全耐药鲍氏不动杆菌相关耐药基因的流行情况。方法对临床分离的17株鲍氏不动杆菌进行菌株鉴定和药敏试验,并运用PCR方法检测相关耐药基因。结果17株鲍氏不动杆菌对医院检测的抗菌药物全部耐药;17株菌中TEM-1、OXA-23、OXA-27、gyrA和AmpC基因的检出率为100.0%,2株菌携带aacC1基因(11.8%),9株菌携带PER-1基因(52.9%)。结论医院鲍氏不动杆菌流行株主要携带TEM-1、OXA-23、OXA-27、gyrA、AmpC、aacC1和PER-1等多个耐药基因,基因型与表型基本一致,临床工作中医生应重视全耐药鲍氏不动杆菌的诊断与治疗,减少交叉感染的发生,加强医院感染的控制。
OBJECTIVE To investigate the prevalence of drug-resistant genes in seventeen strains of all-resistant Acinetobacter baumannii. METHODS Microdilute tests were performed to detect the susceptibility of 17 A. baumannii strains to 16 kinds of antimicrobial agents and antimicrobial-resistant genes were detected by PCR methods. RESULTS Seventeen A. baumannii strains showed all-drug resistance. Genes of TEM-1, OXA-23, OXA-27, gyrA and AmpC were detected in all 17 strains of A. baumannii. The positive rates of aacC31 and PER-1 genes were 11.8% and 52.9 %, respectively. CONCLUSIONS A. baumannii with multi-resistant genes of our hospital carries TEM-1, OXA-23, OXA-27, gyrA, AmpC, aacC1 and PER-1.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2008年第5期619-621,共3页
Chinese Journal of Nosocomiology
关键词
鲍氏不动杆菌
耐药基因
医院感染
Acinetobacterbaumannii
Drug-resistant genes~ Nosocomial infection
