摘要
白血病干细胞被认为是白血病发生、发展及治疗后复发的根源,具有其特异的性状特征,以及自我更新、增殖和分化等能力。近年来以白血病干细胞作为治疗靶点已成为白血病治疗的一种新策略,目前的研究主要针对白血病干细胞表面分子、细胞内信号通路及与微环境的相互作用这三方面展开。对白血病干细胞的进一步认识将有助于提供新的更为有效的治疗靶点。
Leukemia stem cells （LSC） have been considered to be the origin of leukemia and the reason why leukemia develops and relapses. LSC have specific phenotypic characteristics, as well as capacities for self-renewal, proliferation, and differentiation. In recent years, targeting LSC has become a new strategy for therapy in leukemia. Researches are mainly focused on three aspects including LSC surface molecules, intracellular signaling pathways, and the interaction with micro-environmental elements. Further understanding on LSC may provide a variety of more effective novel therapeutic targets for the treatment of leukemia.
出处
《细胞生物学杂志》
CSCD
2008年第2期157-160,共4页
Chinese Journal of Cell Biology
基金
国家基础研究发展规划(973计划)(No.2004CB518804)
浙江理工大学科研启动基金项目(No.0616066-Y)资助~~
关键词
白血病干细胞
靶向
治疗
leukemia stem cells
target
therapy
