摘要
目的观察无功能移植肾切除对肾移植受者群体反应抗体(panelreactiveantibody,PRA)及再次肾移植的影响。方法收集我院2004-2007年收治的15例移植肾切除患者,分别于肾移植前,移植肾切除前,移植肾切除后1个月、半年、1年检测其PRA水平,同时行移植肾病理检查。部分患者经HLA配型检查后进行再次肾移植。结果肾移植后受者PRA高于移植前,移植肾切除后1个月PRA水平进一步升高,在移植后半年及1年后逐渐降低。采用LAT板检查可发现新的HLA致敏位点,肾脏病理检查肾间质有多量C4d沉积。通过HLA配型避开致敏位点选择供肾,7例患者行再次肾移植均获成功。结论移植肾切除可导致血清中PRA水平显著升高,PRA检查可发现新的HLA致敏位点,经良好HLA配型不影响再次肾移植。
Objective To observe the impact of transplant nephrectomy on panel reactive antibodies and a secondary renal transplantation. Methods Panel reactive antibodies in 15 patients with a failed renal transplant admitted in our hospital between 2004 to 2007 were measured before transplantation, before and 1 month, 6 months, 12 months after transplant nephrectomy, and the pathological changes were observed after transplant nephrectomy. Results Panel reactive antibodies was increasing after renal transplantation, and reached the highest level one month after transplant nephrectomy, then granduaUy got down. New HLA allosensitization sites were discovered after transplant nephrectomy. Large amount of CAd was stained in failed transplant. Conclusion Serum PRA increased after transplant nephrectomy. New HLA aUosensitization sites were found, which may be useful in HLA matching.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2008年第10期986-988,共3页
Journal of Third Military Medical University
关键词
肾移植
群体反应抗体
移植免疫
kidney transplantation
panel reactive antibody
transplantation immunity
