摘要
瘦素是由肥胖基因（obesegene）编码、主要是脂肪组织合成并分泌的一种激素，具有调控摄食和能量消耗、抑制细胞凋亡、促进细胞增殖和血管发生的作用。瘦素与其受体在乳腺癌、结肠癌等人类肿瘤有异常高表达，本文将从瘦素及其受体的结构特点、介导的主要信号通路与其促肿瘤发生机制三方面作一综述。
Leptin, a product of the obese （ob） gene, is a multifunctional hormone produced predominantly by adipocytes. Leptin has been theorized to have several functions in regulating food intake and energy expenditure , inhibiting cell apoptosis, promoting proliferation and angiogenesis in both normal and tumor cells. The expression levels of leptin and leptin receptor （OB-R） have been shown to be significantly elevated in a variety of human cancers such as breast cancer,colon carcinoma. The purposes of this review are as follows： to describe the construction features of leptin and its receptors; to explain the principal signalling transduction pathways activated by leptin; and to review the major advances leading to the current understanding of the role of leptin in the pathogenesis of a variety of cancers.
出处
《国际呼吸杂志》
2008年第1期34-37,共4页
International Journal of Respiration
关键词
瘦素
信号转导
生长因子
肿瘤
Leptin
Signal transduction
Growth factor
Tumor
