摘要
目的:探讨缺氧诱导因子-1α(H IF-1α)和血管内皮生长因子(VEGF)在大肠癌组织中的表达及其与大肠癌临床病理特征的关系。方法:免疫组化法检测61例大肠癌组织中H IF-1α及VEGF蛋白表达,并与15例正常大肠组织比较。结果:大肠癌组织中H IF-1α和VEGF的阳性表达率分别为54.10%(33/61)和62.30%(38/61),均明显高于正常对照组(P<0.05);两者呈正相关(r=0.505,P<0.05);Dukes分期中的表达存在显著差异(P<0.05);组织学分级中的表达则无差异性(P>0.05)。结论:H IF-1α及VEGF在肿瘤血管生成和转移中起重要作用,联合检测H IF-1α和VEGF可作为判断大肠癌转移潜能和预后的重要指标。
Objective To investigate the expression of hypoxia inducible factor - 1α （ HIF - 1α ） and vascular endothelial growth factor（VEGF） and their clinicopathological characteristics in colorectal carcinomas. Methods The expression of HIF - lα and VEGF in 61 colorectal carcinomas and 15 normal colorectal tissues was determined by using immunohistoehemical SP method. Results The average positive rate of HIF - let and VEGF was 54.10% （33/61） and 62.30% （38/61）, in colo- rectal carcinomas ,respectively,which was significantly higher than those in normal colorectal tissues（ P 〈 0.05 ）. There was a direct correlation between the expression of HIF - lα and VEGF in colorectal carcinomas （ r = 0.505, P 〈 O. 05 ）. Both HIF - 1 α and VEGF were associated with Dukes stage in colorectal carcinomas （ P 〈 0.05 ）. However, there was no correla- tion between the expression of HIF - lα,VEGF and histological stage（ P 〉 0.05 ）. Conclusion Both HIF - let and VEGF may play important roles in the carcinogenesis and aggression in colorectal carcinomas. Both HIF - 1 α and VEGF may be useful markers to evaluate the potential metastasis and prognosis of colorectal carcinomas.
出处
《郧阳医学院学报》
2008年第2期126-128,F0004,共4页
Journal of Yunyang Medical College
关键词
缺氧诱导因子-lα
血管内皮生长因子
大肠癌
Hypoxia inducible factor- 1 alpha
Vascular endothelial growth factor
Colorectal carcinomas
