摘要
目的观察大剂量单唾液酸四己糖神经节苷脂(GM1)对老年糖尿病患者发生急性缺血性脑梗死的临床效果。方法将41例急性脑梗死的老年糖尿病患者随机分为GM1组和胞二磷胆碱组。两组分别将GM1注射液200mg和胞二磷胆碱0.75g加入0.9%氯化钠100ml中,静脉滴注,1次/d,30d为一疗程。分别在治疗前后进行神经功能缺损评分及日常生活活动量表(BI指数)评分。结果两组患者组内治疗前后神经功能缺损评分及BI指数间差异均有统计学意义(P<0.01),治疗后GM1组的神经功能缺损评分及BI指数评分较胞二磷胆碱组差异有统计学意义(P<0.01)。结论大剂量GM1对老年糖尿病患者发生急性缺血性脑梗死的神经功能改善和生活质量提高有重要意义。
Objective To observe the clinical efficacy of a larger dosage of monosialotetrahexosyl ganglioside （ GM1 ） for acute cerebral infarction in elderly patients with diabetes. Methods Totally 41 elderly diabetes patients with acute cerebral infarction were randomly assigned to GM1 therapy group and citicoline group; 200 mg GM1 injection and 0. 75g citicoline in 100ml 0. 9% sodium chloride were given respectively by intravenous drip, once a day, in course of 30 days. The efficacy was assessed by the stroke scores and BI index before and after treatment. Results The scores before and after treatment in both groups showed remarkable differences （ P 〈 0. 01 ） , and the scores in GM1 group were better than those of citicoline group after treatment （ P 〈 0. 01 ）. Conclusion A larger dosage of monosialotetrahexosyl ganglioside for acute cerebral infarction in elderly patients with diabetes plays an important role in improving nerve function and increasing quality of life.
出处
《中国全科医学》
CAS
CSCD
2008年第9期801-802,共2页
Chinese General Practice
基金
2004年陕西省科技发展计划项目[2004K16-G10(1)]
关键词
神经节苷脂
脑梗死
糖尿病
G （M1） Ganglioside
Brain infarction
Diabetes mellitus
