摘要
2型糖尿病可显著增加结直肠肿瘤风险，高胰岛素血症在此过程中起重要作用。胰岛素可增加胰岛素样生长因子-1（IGF-1）的活性，临床、血清学、动物模型、细胞培养等研究显示，IGF-1及胰岛素可促进结直肠肿瘤的发生。流行病学研究发现，糖尿病病程、血糖、糖化血红蛋白、外源性胰岛素及药物治疗、体重指数等均与结直肠肿瘤的风险有关。
Type 2 diabetes is associated with a significant increased risk of colorectal tumor. Hyperinsulinemia plays an important role in the correlation between diabetes and colorectal tumor. Insulin increases the activity of insulin-like growth factor-1 （IGF-1）. Clinical evidence, serologic study, animal model, cell culture supported high levels of insulin and IGF-1 may promote colorectal carcinogenesis. And epidemiologic evidence found that the course of type 2 diabetes, blood glucose, glycosylated hemoglobin, treatment of exogenous insulin and drug,body mass index,ere are related to increased risk of colorectal tumor.
出处
《国际内分泌代谢杂志》
2008年第3期195-197,共3页
International Journal of Endocrinology and Metabolism
关键词
2型糖尿病
结直肠肿瘤
高胰岛素血症
Type 2 diabetes mellitus
Colorectal tumor
Hyperinsulinemia
