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Parkinson病患者认知功能障碍与失匹配负波相关性研究 被引量:4

Cognitive Dysfunction and Mismatch Negativity in Patients with Parkinson's Disease:A Correlation Study
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摘要 目的:探讨失匹配负波(MMN)与额叶认知功能测试在评价Parkinson病(PD)患者认知功能中的作用及其临床价值。方法:对28例早期非痴呆非抑郁PD患者和31例年龄、教育年限相匹配的正常对照组分别进行额叶认知功能测试和MMN测定。结果:与正常对照组相比,非痴呆非抑郁PD患者额叶认知测试评分较差,MMN潜伏期延长(P<0.001);波幅虽呈下降趋势,但无统计学意义;MMN潜伏期延长与额叶认知功能障碍程度呈正相关(P<0.01~0.05)。结论:MMN能较客观地反映非痴呆非抑郁PD患者早期额叶认知功能障碍。 Objective: To investigate the effects of the tests of mismatch negativity (MMN) and prefrontal cognitive function on the evaluation of cognitive function in patients with Parldnson's disease (PD) and their clinical value. Methods: Twenty-eight patients with early non-dementia and non-depression PD and 31 normal controls matched by sex and educational background were determined by the tests of prefrontal cognitive function and MMN. Results: As compared with the normal control group, the test of prefrontal cognition scores in patients with non-dementia and non-depression PD were lower, and the MMN latency was prolonged; wave amplitude was tending to reduce, but there was no statistical significance; the prolonged MMN latency was positively correlated with the severity of prefrontal cognitive dysfunction. Conclusions: MMN may more objectively reflect the early prefrontal cognitivedysfunction in patients with non-dementia and non-depression PD.
出处 《中华脑血管病杂志(电子版)》 2008年第2期82-84,共3页 Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
关键词 PARKINSON病 认知障碍 失匹配负波 Parkinson's disease cognitive dysfunction mismatch negativity
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