摘要
目的:比较胺碘酮与索他洛尔治疗心房颤动(AF)的成本与效果。方法:102例患者均分成A、B组,分别给予胺碘酮、索他洛尔治疗,并进行成本-效果分析。结果:2组成本分别为2714.18、2176.56元,有效率分别为78.43%、70.59%(P<0.01),不良反应发生率分别为13.73%、19.61%(P<0.01)。结论:胺碘酮转复房颤有效率与索他洛尔相当,但维持窦律疗效优于索他洛尔,对心脏毒副作用小于索他洛尔。
OBJECTIVE： To evaluate the cost - effectiveness of amiodarone versus sotalol for Atrial fibrillation. METHODS： A total of 102 patients with atrial fibrillation were treated with amiodarone （Group A） or sotalol （Group B） . The cost - effectiveness analysis was performed on two groups. RESULTS： The total cost in Group A was 2 714.18 yuan versus 2 176.56 yuan in Group B; the effective rates were 78.43% vs. 70.59% （P〈0.01）; and the incidences of adverse drug reactions （ADRs） was la. 7a% vs. 19.61% （P 〈 0.01）. CONCLUSION ： There is no significant difference between amiodarone and sotalol in effective rate of converting atrial fibrillation to sinus rhythm. However amiodarone is more effective than sotalol in maintenance of sinus rhythm. The ADR of amiodarone on heart is less severe than that of sotalol.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第14期1046-1047,共2页
China Pharmacy
关键词
心房颤动
胺碘酮
索他洛尔
成本-效果分析
Atrial fibrillation
Amiodarone
Sotalol
Cost - effectiveness analysis
