摘要
目的:观察经皮冠状动脉介入治疗(PCI)术前后^(99m)Tc—MIBI心肌灌注显像的变化,筛选PCI疗效可靠的预测指标。方法:48例心肌梗死患者PCI前分别行静患/运动/硝酸甘油介入^(99m)Tc—MIBI心肌灌注显像,PCI术后1～2周复查运动和静息^(99m)Tc—MIBI心肌灌注显像,以(术后静息心肌灌注显像缺损计分-术前运动心肌灌注显像缺损计分)/术前运动灌注缺损计分作为PCI术的疗效,以(术前静息心肌灌注缺损计分-术前运动心肌灌注缺损计分)/术前运动灌注缺损计分作为术前有功能存活心肌的指标、以(术前运动心肌灌注缺损计分-术前硝酸甘油心肌灌注缺损计分)/术前运动灌注缺损计分作为潜在有功能存活心肌的指标、以(术前静息心肌灌注缺损计分-术前硝酸甘油心肌灌注缺损计分)/术前静息灌注缺损计分作为药物可改善存活心肌指标。后三者分别与PCI术后疗效作直线相关分析。筛选PCI疗效可靠的预测指标。结果:PCI后运动和静息心肌灌注显像比术前均明显改善(P<0.01)。相关分析结果表明,后三者与前者相关系数分别为:r_1=0.63.P<0.01;r_2= 0.94,P<0.0001;r_3=0.92,P<0.000 1,提示潜在有功能存活心肌与PCI疗效相关性最佳。结论:心肌梗死患者PCI前进行静息/运动/硝酸甘油介入^(99m)Tc-MIBI心肌灌注显像很有必要,潜在有功能存活心肌可作为筛选PCI患者和预测PCI疗效的可靠指标。
Objective：To observe the ^99mTc-MIBI myocardial perfasion images in patients with myocardial infarction before/ after percutaneous coronary intervention （PCI）, so as to screen for the reliable predictors for the therapeutic effect of PCI. Methods：Forty-eight patients with myocardial infarction receiving PCI were included in this study. The rest, stress and nitroglycerin myocardial perfusion imaging tests were performed before PCI. The stress and rest myocardial perfusion imaging tests were repeated 1-2 weeks after PCI. The value of（rest ^99mTc-MIBI imaging in myocardial perfusion scores after PCI-stress ^99mTc-MIBI imaging in myocardial perfusion scores before PCI）/ stress ^99mTc-MIBI imaging in myocardial perfusion scores before PCI was taken as the curative effect of PCI; the value of（rest ^99mTc-MIBI imaging in myocardial perfusion scores before PCI-stress ^99mTc-MIBI imaging in myocardial perfusion scores before PCI）/ stress ^99mTc-MIBI imaging in myocardial perfusion scores before PCI was taken as the functional viable myocardium, the value of （stress ^99mTc-MIBI imaging in myocardial perfusion scores before PCI-nitroglycer ^99mTc-MIBI imaging in myocardial perfusion scores before PCI）/ stress ^99mTc-MIBI imaging in myocardial perfusion scores before PCI was taken as potential functional viable myocardium; and the value of（rest ^99mTc-MIBI imaging in myocardial perfusion scores before PCI-nitroglycer ^99mTc-MIBI imaging in myocardial perfusion scores before PCI）/ rest ^99mTc-MIBI imaging in myocardial perfusion scores before PCI was taken as drug relative viable myocardium. To screen the proper predictors for therapeutic effects, linear correlation analysis was performed between the curative effect of PCI and the latter 3 factors. Results： Stress and rest myocardial perfusion defects were significantly improved after PCI （P〈 0.01）. Correlation analysis showed that the curative effect of PCI was correlated with the latter 3 factors, with the correlation coefficients being r1= 0
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2008年第5期531-534,共4页
Academic Journal of Second Military Medical University
