摘要
目的:制备盐酸噻氯匹定分散片,考察辅料对其崩解、溶出性能及混悬液稳定性的影响。方法:以崩解时限和可压性为指标进行单因素考察,选择适宜的崩解剂、崩解剂用量、黏合剂的浓度和润滑剂。设计正交试验,以崩解时限、2min溶出量及混悬液稳定性为指标进行处方优选。结果:优选处方在60s内完全崩解,药物溶出迅速,符合分散片的各项评价指标。结论:崩解剂的种类、用量、加入方法及黏合剂、润滑剂等因素均对盐酸噻氯匹定分散片的性能有明显影响。
OBJECTIVE To prepare ticlopidine hydrochloride dispersible tablets and investigate factors affecting disintegration time. dissolution rate and suspensibility. METHODS Single factor investigations were performed to choose suitable disin tegrants, lubricants and adhesion agent. Orthogonal design was used to choose the best formulation , with dissolution results, disintegration time and the suspensibility as indices. RESULTS The optimized formulation tablets were fine in appearance, disintegarating within 60 s,and with rapid dissolution rate. CONCLUSION The preparation and the quality of dispersible tablets were affected by the category and amount of diluents、disintegrants、adhesion agent and lubricants.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第8期617-620,共4页
Chinese Journal of Hospital Pharmacy
关键词
盐酸噻氯匹定
分散片
正交试验
崩解时限
ticlopidine hydrochloride
dispersible tablet
orthogonal design
disintegration time
