摘要
B型胰岛素抵抗综合征是一种严重胰岛素抵抗状态,是由于循环中存在针对胰岛素受体的抗体所引起的自身免疫综合征,常表现为严重胰岛素抵抗如高血糖、高胰岛素血症、黑棘皮病或顽固性低血糖,大部分患者合并有系统性红斑狼疮等自身免疫性疾病。目前认为胰岛素受体自身抗体的产生是机体免疫调节紊乱所致,而抗体作用的机制未明。B型胰岛素抵抗综合征的确诊有赖于体内胰岛素受体自身抗体的检测。国外文献报道应用免疫抑制剂可以使部分患者病情缓解,但其预后表现为多样化。
Type B insulin resistance syndrome is an autoimmune syndrome that causes target-cell insulin resistance, It is characterized mainly by hyperglycemia, intractable hypoglycemia, endogenous hyperinsulinemia and some other severe insulin resistance manifestations, patients often have a coexistent autoimmune disorder, such as systemic lupus erythematosus ( SLE). The syndrome is caused by autoantibodies to insulin receptor in the blood circulation, these autoantibodies may be the result of immunological disorders, but the exact mechanism remains to be clarified. The diagnosis of the syndrome depends on the detection of autoantibodies to insulin receptor besides the major clinical manifestations. Although the prognosis of the syndrome is quite different, immunosuppressive therapy seems to be responsible for some patient's remission.
出处
《国际内科学杂志》
CAS
2008年第4期234-237,共4页
International Journal of Internal Medicine