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B型胰岛素抵抗综合征 被引量:9

Type B insulin resistance syndrome
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摘要 B型胰岛素抵抗综合征是一种严重胰岛素抵抗状态,是由于循环中存在针对胰岛素受体的抗体所引起的自身免疫综合征,常表现为严重胰岛素抵抗如高血糖、高胰岛素血症、黑棘皮病或顽固性低血糖,大部分患者合并有系统性红斑狼疮等自身免疫性疾病。目前认为胰岛素受体自身抗体的产生是机体免疫调节紊乱所致,而抗体作用的机制未明。B型胰岛素抵抗综合征的确诊有赖于体内胰岛素受体自身抗体的检测。国外文献报道应用免疫抑制剂可以使部分患者病情缓解,但其预后表现为多样化。 Type B insulin resistance syndrome is an autoimmune syndrome that causes target-cell insulin resistance, It is characterized mainly by hyperglycemia, intractable hypoglycemia, endogenous hyperinsulinemia and some other severe insulin resistance manifestations, patients often have a coexistent autoimmune disorder, such as systemic lupus erythematosus ( SLE). The syndrome is caused by autoantibodies to insulin receptor in the blood circulation, these autoantibodies may be the result of immunological disorders, but the exact mechanism remains to be clarified. The diagnosis of the syndrome depends on the detection of autoantibodies to insulin receptor besides the major clinical manifestations. Although the prognosis of the syndrome is quite different, immunosuppressive therapy seems to be responsible for some patient's remission.
作者 曾映娟 程桦
出处 《国际内科学杂志》 CAS 2008年第4期234-237,共4页 International Journal of Internal Medicine
关键词 B型胰岛素抵抗综合征 胰岛素抵抗 胰岛素受体自身抗体 Type B insulin resistance syndrome Insulin resistance Autoantibodies to insulin receptor
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  • 1Goldfine AB, Moses AC. Syndrome of extreme insulin resistance. In. Kahn CR, King GL, Moses AC, et al. eds. Joslin g Diabetes Mellitus. 14th ed. Philadelphia:Lippincott Williams & Wilkins, 2005, 493-505. 被引量:1
  • 2Tritos NA, Mantzoros CS. Clinical review 97 : Syndromes of severe insulin resistance. J Clin Endocrinol Metab, 1998, 83 (9) : 3025-3030. 被引量:1
  • 3Field JB,Johnson P, Herring B. Insulin -resistant diabetes associated with increased endogenous plasma insulin followed by complete remission. J Clin Invest, 1961,40:1672- 1683 被引量:1
  • 4Flier JS, Kahn CR, Roth J, et al. Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science, 1975,190 (4209) : 63- 65 被引量:1
  • 5Kahn CR, Flier JS, Bar RS, et al. The syndromes of insulin resistance and acanthosis nigricans, Insulin-receptor disorders in man. N Engl J Med, 1976,294(14) : 739-745. 被引量:1
  • 6袁凤山,齐今吾.B型胰岛素抵抗:一例报告及讨论[J].中华内分泌代谢杂志,2004,20(3):278-278. 被引量:7
  • 7蒋克春,饶亚平,庞春梅,王爱萍,刘艳存.糖尿病伴严重胰岛素抵抗报告[J].实用糖尿病杂志,2005,1(6):45-46. 被引量:4
  • 8刘丹,杨川,陈黎红,蔡梦茵,李焱,曾映娟,严励,程桦.B型胰岛素抵抗综合征一例及文献复习[J].中华内分泌代谢杂志,2008,24(2):227-228. 被引量:4
  • 9Rodriguez 0, Collier E, Arakaki R, et al. Characterization of purified autoantibodies to the insulin receptor from six patients with type B insulin resistance. Metabolism, 1992,41 : 325-331. 被引量:1
  • 10Pirro R, Roth RA, Rossetti L, et al. Characterization of the serum from a patient with insulin resistance and hypoglycemia. Evidence for multiple populations of insulin receptor antibodies with different receptor binding and insulin-mimicking activities. Diabetes, 1984, 33 ( 3 ) :301-304. 被引量:1

二级参考文献12

  • 1袁凤山,齐今吾.B型胰岛素抵抗:一例报告及讨论[J].中华内分泌代谢杂志,2004,20(3):278-278. 被引量:7
  • 2蒋克春,饶亚平,庞春梅,王爱萍,刘艳存.糖尿病伴严重胰岛素抵抗报告[J].实用糖尿病杂志,2005,1(6):45-46. 被引量:4
  • 3Goldfine AB, MosesAC. Syndrome of extreme insulin resistance. In: Kahn CR, et al (eds). Joslin' s Diabetes Mellitus. 14^th ed. Philadelphia- Lippincott Williams & Wilkins, 2005,493-505. 被引量:1
  • 4Tritos NA, Mantzoms CS. Clinical review: Syndromes of severe insulin resistance. J Clin Endocrinol Metab, 1998,83:3025-3030 被引量:1
  • 5Flier JS, Kahn CR, Roth J, et al. Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science, 1975,190:63-65. 被引量:1
  • 6Kahn CR, Flier JS, Bar RS, et al. The syndromes of insulin resistance and acanthosis nigricans. Insulin receptor disorders in man. N Engl J Med, 1976,294:739-745. 被引量:1
  • 7Arioglu E, Andewelt A, Diabo C, et al. Clinical course of the syndrome of autoantibodies to the insulin receptor ( type B insulin resistance) : a 28-year perspective. Medicine, 2002,81:87-100. 被引量:1
  • 8Arioglu E, Andewelt A, Diabo C, et al. Clinical course of the syndrome of autoantibodies to the insulin receptor (type B insulin resistance): a 28-year perspective. Medicine, 2002,81:87-100. 被引量:1
  • 9Tsokos GC, Gorden P, Antonovych T, et al. Lupus nephritis and other autoimmune features in patients with diabetes mellitus due to autoantibody to insulin receptors. Ann Intern Med, 1985,102:176-181. 被引量:1
  • 10Bloise W,Wajchenberg BL, Moncada VY, et al. Atypical antiinsulin receptor antibodies in a patient with type B insulin resistance and scleroderma. J Clin Endocrinol Metab, 1989,68:227-231. 被引量:1

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