他汀类药物在风湿性疾病中的应用
摘要
他汀类药物或称作羟基甲基戊二酸单酰辅酶A（HMG—CoA）抑制剂作为降低胆固醇的药物，不仅能降低低密度脂蛋白和提高高密度脂蛋白水平，还能提高内皮细胞的功能，抑制炎症介质、抑制内膜增厚、减少促炎症因子的分泌。最近发现他汀类药物可能对风湿性疾病如系统性红斑狼疮（SLE）、类风湿关节炎（RA）、骨关节炎（OA）等有治疗作用。现将他汀类药物的抗炎和免疫调节作用机制及在风湿性疾病的应用综述如下。
出处
《中华风湿病学杂志》
CAS
CSCD
2008年第5期349-352,共4页
Chinese Journal of Rheumatology
参考文献23
-
1Paoletti R, Bolego C, Cignarella A. Lipid and non-lipid effects of statins. Hand Exp Pharmacol, 2005, 170: 365-388. 被引量：1
-
2Stalker TJ, Lefer AM, Scalia R. A new HMG-CoA reductase hibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001, 133: 406-411. 被引量：1
-
3Nawawi H, Osman NS, Annuar R, et al. Soluble intercellular adhesion molecule-1 and interleukin-6 levels reflect endothelial dysfunction in patients with primary hypercholesterolaemia treated with atorvastatin. Atherosclerosis, 2003, 169: 283-291. 被引量：1
-
4Fischetti F, Carretta R, Borotto G, et al. Fluvastatin treatment inhibits leucocyte adhesion and extravasation in models of complement-mediated acute inflammation. Clin Exp Immunol, 2004, 135: 186-193. 被引量：1
-
5Weitz-Schmidt G, Welzenbach K, Dawson J, et al. Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by X-ray analysis and monitoring of LFA-1 conformational changes in vitro and exvivo. J Biol Chem, 2004, 279: 46764-46717. 被引量：1
-
6Han KH, Ryu J, Hong KH, et al. HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor-2 expression and mo-nocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. Circulation, 2005, 111: 1439-1447. 被引量：1
-
7Kalinowski L, Dobrucki IT, Malinski T. Cerivastatin potentiatesnitric oxide release and eNOS expression through inhibition of isoprenoid synthesis. J Physiol Pharmacol, 2002, 53: 585-595. 被引量：1
-
8Wagner AH, Schwabe O, Hecker M. Atorvastatin inhibition of cytokine-inducible nitric oxide synthase expression in native endothelial cells in situ. Br J Pharmacol, 2002, 136: 143-149. 被引量：1
-
9Wassmann S, Laufs U, Baumer AT, et al. Inhibition of geranylgeranylation reduces angiotensin Ⅱ -mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Racl GTPase. Mol Pharmacol, 2001, 59:646-654. 被引量：1
-
10Luan Z, Chase A J, Newby AC. Statins inhibit secretion of metal loproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol, 2003, 23: 769-775. 被引量：1
-
1吴越（摘）.有种降压药能“防”糖尿病眼病[J].糖尿病天地（文摘刊）,2008(7):18-18.
-
22013年糖尿病学小幅进步[J].中国全科医学（医生读者版）,2013,16(12):71-73.
-
3高键.胆固醇高能吃海鲜吗[J].健康伴侣,2007(11):51-51.
-
4苏智军,柯邵鹏,林永年,史美育,张奕返,李跃平.重型肝炎、活动性肝硬化医院感染预后因素分析[J].中国医师杂志,2002,4(8):806-808. 被引量：1
-
5李宏建.大剂量阿托伐他汀对稳定型冠心病患者脑血管事件的作用[J].国际脑血管病杂志,2006,14(12):895-895.
-
6高胆固醇不损老年人健康[J].现代临床医学生物工程学杂志,1997,3(3):196-196.
-
7宋振坤.红曲能否代替他汀类药物[J].心血管病防治知识,2010(1):58-59.
-
8阿伐他汀可以减轻不稳定性心绞痛患者的炎症[J].基础医学与临床,2006,26(7):760-760.
-
9吴水珍.辛伐他汀治疗冠心病合并高脂血症的疗效观察[J].实用医技杂志,2010,17(5):453-454. 被引量：1
-
10李之一（摘）.轻度脂肪肝患者需要吃药吗[J].中外健康文摘,2008,5(7):43-43.
