摘要
长期以来，巨噬细胞移动抑制因子（MIF）一直是一种功能不明的细胞因子。最近几年的研究发现，MIF是宿主抗微生物预警系统和应急反应（可以促进免疫细胞促炎症功能）的一个必要组成成份，是一种对固有免疫反应具有关键性调节作用的重要分子。研究表明，MIF参与了包括脓毒症、炎症和自身免疫性炎症疾病在内的一系列疾病的发病机制，这为未来使用靶向MIF疗法治疗相关的人类疾病提供了全新的思路。
For more than three decades, macrophage migration inhibitory factor （MIF） has been a mysteri- ous cytokine with unknown function. Researches in recent years found that MIF is an essential component of the host antimicrobial alarm system and stress response which can promote the pro-inflammatory functions of immune cells, and it is a crictical molecule playing a role in regulating innate immune response. Recent evidences show that MIF is involved in the pathogenesis of sepsis, inflammation , and auotoimmune inflammatory diseases, and offer novel strategy to treat these diseases by targetting MIF.
出处
《国际免疫学杂志》
CAS
2008年第3期209-214,共6页
International Journal of Immunology
关键词
巨噬细胞移动抑制因子
固有免疫
脓毒症
炎症
自身免疫性炎症疾病
Macrophage migration inhibitory factor
Innate immunity
Sepsis
Inflammation
Autoimmuneinflammatory disease
