摘要
对左氟沙星和氧氟沙星在健康志愿者中的药动学进行了研究。以高效液相色谱法测定血、尿药物浓度。两种药物平均药动学参数间的差异以ｔ检验处理。结果表明，８名健康志愿者ｐｏ左氟沙星和氧氟沙星２００ｍｇ后的体内过程均符合二房室模型。Ｃｍａｘ分别为３．０６±０．７０ｍｇ／Ｌ和３．４７±１．３３ｍｇ／Ｌ，ＡＵＣ分别为１４．８０±２．１０ｍｇ·ｈ／Ｌ和１７．５２±４．７４ｍｇ·ｈ／Ｌ，两者间的差异均无统计学意义，Ｔｍａｘ和ｔ１／２β等其他药动学参数均相近。根据研究结果，左氟沙星片剂用于临床治疗敏感菌所致各种感染时其日剂量约为氧氟沙星的半量。
The study was conducted in 8 healthy volunteers,drug level in serum and urine were determined by HPLC and the pharmacokinetic parameters were treated by T test.Results showed that a two department model are fitted with a C max and AUC of 3.06±0.70 mg/L and 14.80±2.10 mg·h/L for levofloxacin and 3.47±1.33 mg/L and 17.52±4.74 mg·h/L for ofloxacin respectively.No statistically significant defferences were observed.Other parmeters T max and t 1/2 β etc were also similar.It is suggested from these results that the dosage of levofloxacin is half of that of ofloxacin in treatment of clinical infections.
出处
《中国新药杂志》
CAS
CSCD
1997年第5期376-378,共3页
Chinese Journal of New Drugs
