摘要
目的探讨急性冠脉综合征患者血浆NT-proBNP(N末端脑钠肽前体)浓度和hs-CRP(血清高敏C反应蛋白)水平,与急性冠脉综合征患者近期预后的关系。方法采用荧光免疫抗原抗体结合法和免疫比浊法测定血浆BNP浓度(正常值<300fmol/ml)和血清hs-CRP水平(正常值<3mg/L),并平均随访246天,观察随访期主要不良心脏事件。结果患者hs-CRP>3.5mg/l,NT-proBNP>500pg/l比低于次2项数值患者心血管事件发生率高出11%。结论ACS患者hs-CRP和NT-proBNP的升高水平急性冠脉综合征患者随访期内MACE发生的独立预测因素。
Objective To evaluate the correlations of serum N-terminal ProB-type natriuretic peptide and C-reactive protein levels and prognosis in patients with acute coronary syndrome during 246 days follow-up. Methods Serum N-terminal ProB-type natriuretic peptide and C-reactive protein concentrations were measured by fluoroimmunoassay and immunonephelometry. The patiets were followed up for 246 days and the main adverse cardiovascular events. Results The baseline levels of N- terminal ProtB-type natriuretic peptide and C-reactive protein were significantly higher in the patients with cardiac events than in those without events. After adjustment for major clinical prognostic factirs. N-terminal ProB-type natriuretic peptide and C-reactive protein remained significantly independent predictors for cardiac events. Patients with hs-crp level〉 3.5 mg/L and Nt-probnp level〉 500 pg/L had an 11- hopld higher risk for cardiac events than those with hs-crp level〈3.5mg/L and Nt-probnp level〈500 pg/L. Conclusions Serum Nt-proBNP and hs-crp level is a indenpent predictor for 246days MACE rate in patients with ACS.
出处
《齐齐哈尔医学院学报》
2008年第6期651-653,共3页
Journal of Qiqihar Medical University
关键词
急性冠脉综合征
C反映蛋白
N末端脑钠肽前体
N-terminal probrain natriuretic peptide Acute coronary syndromes C-reactive protein Main adverse cardiovascular events