摘要
目的探讨血清甲胎蛋白（AFP）定量测定值与重型病毒性肝炎预后的关系。方法回顾性分析213例重型病毒性肝炎患者AFP测定结果及不同水平的分布。结果AFP异常率68．1％，急性重型肝炎AFP异常率明显低于亚急性重型肝炎及慢性重型肝炎（P〈0．01）。AFP〈20μg／L患者的病死率86．8％，AFP20-400μg／L患者病死率58．8％，AFP〉400μg／L患者病死率20．9％。213例重型肝炎存活85例，AFP（248．0±72．5）μg／L；死亡128例，AFP（97．6±50．4）μg／L，两者比较差异有统计学意义（P〈0．01）。结论随着AFP水平的升高，重型病毒性肝炎病死率下降，生存率逐渐升高，提示重型病毒性肝炎患者血清AFP水平可作为判断预后的重要指标。
Objective The objective of this study was to explore the relations of quantitatively measurment of serum alphafetoprotein（AFP） and prognosis in severe viral hepatitis. Methods To retrospectively analyse the different level of quantitatively measurment of serum alphafetoprotein（AFP） and distribution of AFP in 213 patients with severe viral hepatitis. Results The abnormity rate of AFP was 68.1% , the abnormity rate of AFP in acute severe hepatitis patients was significantly less than that in subacute severe hepatitis and chronic severe hepatitis（P 〈 0.01 ）, the death rate of patients with AFP 〈 20μg/L, AFP, 20- 400μg/Land AFP 〉 400μg/L was 86.8 %, 58.8 % and 20.9 % respectively, the survival severe hepatitis patients were 85 cases with AFP（248.0±72.5）±g/L in 213 cases, 128 cases with AFP（97.6±50.4 ）μg/L died （ P 〈 0.01 ）. Conclusion The mortality of severe decreases and the survival rates of severe increases gradually along with the higher level of AFP, and it reveals the higher level of AFP in severe hepatitis has a better prognosis,it is the important reference index of prognostic judgement.
出处
《中国基层医药》
CAS
2008年第3期355-356,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
甲胎蛋白类
肝炎
病毒性
人
预后
Alpha-fetoproteins
Hepatitis, viral, human
Prognosis
