摘要
目的建立非控制性脾大部损伤出血性休克模型,比较低压复苏与常压复苏抢救的效果。方法脾部分切除模拟人失血低压状态下,建立类似人休克的模型后,将动物随机分成4组。1组,假手术组;2组,休克未处理组;3组,正常血压复苏组;4组,低压复苏组。观察其成活率及对内脏的损伤程度。结果动物失血低压抢救比常压抢救存活时间长。结论低压可改善组织代谢,提高生存时间,是更为理想的复苏方法。低压复苏非控制性脾大部损伤出血性休克模型的建立,为临床急性大出血提供新的抢救方法。
Objective To establish a rat hypotensive and uncontrolled hemorrhagic shock model, and to compare the difference between normal MAP resuscitation and hypotensive resuscitation groups. Methods Following the model established, fourty Wistar rats were randomly and equally divided into four groups：Group 1, sham-operation group; group 2, untreated shock group;group 3,normal MAP resuscitation group （during acute resuscitation phase MAP was kept at 80 mmHg）, and group 4, hypotensive resuscitation group （during acute resuscitation phase MAP was kept at 60 ± 5 mmHg）. To observe and analyze the survival rate and the degree of organ injuries. Results The survival time of rats in the hypotensive resuscitation group was significantly longer than that of the normal MAP resuscitation group. Conclusions In comparison with normal blood pressure resuscitation, hypotensive resuscitation can improve tissue metabolism and prolong survival time during resuscitation from uncontrolled hemorrhagic shock. Hypotensive resuscitation is a more reliable resuscitation method in comparison with normal blood pressure resuscitation.
出处
《中国比较医学杂志》
CAS
2008年第4期14-17,79,共5页
Chinese Journal of Comparative Medicine
关键词
休克
出血性
非控制
低压复苏
Shock
hemorrhagic
uncontrolled
Hypotensive resuscitation
Rat
