摘要
近10年来,以体外细胞色素P450抑制数据预测潜在临床药物相互作用的方法得到极大发展。药物相互作用(drug-drug interaction)研究一直是临床实践和新药开发中的重要环节。本文对近年来引起广泛重视的机理性灭活作用(mechanismbased inactivation)进行总结分析,综合传统和经简化的鉴定机理性灭活作用方法,并介绍预测体内由机理性灭活引起药物相互作用的模型和影响参数。
In the last decade, the approaches for the in vitro inhibition assessment of the potentials of drug-drug interaction in vivo have received process. DDIs remain an important issue in clinical practice and the development of new drugs. Mechanism-based inactivation is gaining more attention among in vitro study. This review would describe methods in identifying mechanism-based inactivation, and introduce predictive models and parameters in the field.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2008年第3期241-248,共8页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
药物相互作用
不可逆性抑制
机理性灭活
细胞色素P450
体外一体外预测
drug-drug interaction
irreversible inhibition
mechanism-based inactivation
cytochrome P450
in vitroin vivo extrapolation
