摘要
探讨我国围产儿先天性脑积水的流行病学特征，为降低该畸形的发生率提供科学依据。１９８６年１０月至１９８７年９月间，对全国原２９省、市、自治区９４５所医院进行出生缺陷监测，观察对象为妊娠２８周至出生后７天的围产儿。结果：在监测的１２４３２８４例住院分娩的围产儿中，共检出１１４６例先天性脑积水。全国平均发生率为９．２／万，仅次于神经管缺陷发生率；各省发生率波动在４．４～２２．９／万范围。低体重儿（５１．３／万）或早产儿（６０．８／万）中先天性脑积水发生率分别高于正常体重儿（６．１／万，Ｐ＜０．００１）、足月儿（６．２／万，Ｐ＜０．００１）；乡村发生率（１６．５／万）高于城镇（５．６／万，Ｐ＜０．０１）。患儿无性别差异。在检出的病例中，死胎占５０．８％、死产２７．１％、７天内死亡１２．１％，存活的患儿仅占７．７％。２４．３％的先天性脑积水患儿伴有其他畸形。产前诊断病例占３１．９％，其中仅有６．３％进行治疗性引产。先天性脑积水是我国常见且严重的先天畸形，患儿预后较差。
To study the clinical and epidemiologic chracteristics of perinates with congenital hydrocephalus(CHy) in China.Methods:The birth defects monitoring was undertaken in 945 hospitals from 29 provinces,cities and autonomous of China between October 1986 and September 1987.Data about perinate including intrauterine death and stillbirth from 28 weeks of gestation to a period of 7 days after birth was collected through the medical records.Results:A total of 1146 cases with CHy were found in 1243284 perinates monitored.The incidence of CHy in China varied from 44 to 229 with a mean of 92 per 10000,than which the prevalence in Shanxi and Hebei provinces(229,165 per 10000,respectively) was higher(P<001).The prevalence of CHy infants with low birth weight(513 per 10000) or preterm(608 per 10000) respectively was higher than that with normal birth weight(61 per 10000,P<0001) or term(62 per 10000,P<0001),as well as that in the rural area higher than in urban area(165 vs.56 per 10000,P<001).Intrauterine death account for 508% of these cases,stillborn for 271% and early death of neonates for 121%.The survival rate in perinalal period was 77%.243% cases with CHy had other major defects.Only 319% cases with CHy were diagnosied before birth,among which 63% cases were made elective terminated.Conclusions:CHy was one of the major malformatioms which were higher prevalence and higher mortality in China.
出处
《现代预防医学》
CAS
1997年第3期276-279,共4页
Modern Preventive Medicine
关键词
先天性
脑积水
围产儿
流行病学
Congenital hydrocephalus Perinate Epidemiology
