摘要
目的研究狗慢性膝关节炎症期滑膜组织中各种细胞因子(TNF-α,IL-1β,IL-6,IL-10)表达水平。方法Beagle狗17条,分为正常组(n=8)和慢性非感染性炎症组(n=9)。分别取其膝关节滑膜组织,采用ELISA方法检测滑膜组织中各种细胞因子的表达水平。结果与正常组相比,慢性非感染性炎症组滑膜组织内IL-1β、IL-6浓度显著增高(P<0.05),TNF-α、IL-10浓度无明显变化(P>0.05)。结论慢性非感染性炎症期,狗膝关节滑膜组织中IL-1β、IL-6表达显著增加。
Objective To examine the changes in some cytokines （ TNF-α, IL-1β, IL-6, IL-10） in chronic inflamed knee joint synovium tissue of dogs. Methods Knee joint synovium tissue was taken from nine Beagle dogs with chronic knee arthritis and eight dogs with normal knee joints. Cytokines were detected using ELISA. Results The expression of IL-1β and IL-6 in the chronic inflamed group was significantly higher than that in the normal group （ P 〈 0.05 ）. Conclusion Chronic inflammation enhances the expression of IL-1βand IL-6 in knee joint synovium tissue of dogs.
出处
《临床军医杂志》
CAS
2008年第2期178-180,共3页
Clinical Journal of Medical Officers
基金
军队"十一五"面上项目(06MB223)
长征医院"三重三优"人才建设基金资助
