摘要
目的观察自主构建的个体化组织工程骨修复小儿长骨缺损的疗效。方法通过抽取患儿少量骨髓,分离其中的间充质干细胞并在体外进行扩增培养,诱导分化后与脱钙骨基质(DBM)相复合,构建个体化的组织工程骨并应用于临床治疗,通过临床随访其CR以及CT结果评价其疗效。结果15例长骨缺损患儿参与临床试用,随访时间为1年以上,随访资料显示成骨速度快,骨改建良好,且术后随访CR及CT均未发现复发。结论个体化组织工程骨可成功修复小儿长骨缺损。
Objective To investigate the therapeutic effect of the tissue-engineered bone in the treatment of adolescents long bone defects. Methods Fifteen children short of autologous bone or suffered relapse of the osteopathia were studied. Individualized tissue-engineered bone was cultured for the treatment of their long bone defects. Both computed radiography and computed tomography detections were held throughout the follow-up. Results All the cases showed good bone reformation and recanalization of medullary cavity. Recidivism of the primary affection was not found. Conclusion Gratifying outcome of the bone defect repairing suggested that adolescent bone defects could be treated by the tissue-engineered bone made of their own osteocytes.
出处
《华南国防医学杂志》
CAS
2008年第2期1-4,共4页
Military Medical Journal of South China
基金
国家高技术研究发展计划(863计划)重大攻关课题(2006AA02A122)
关键词
组织工程骨
修复
小儿
长骨缺损
放射学观察
Tissue-engineered bone
Repair
Adolescent
Long bone defects
Radiological follow-up
