摘要
目的:探讨了牙周病患者血清IL-8、IL-10、IL-18和M-CSF检测的临床意义。方法:应用放射免疫分析和酶联免疫法对55例牙周病患者进行了治疗前后血清IL-8、IL-10、IL-18和M-CSF水平检测,并与35名正常健康人作比较。结果:牙周病患者在治疗前血清IL-8、IL-10、IL-18和M-CSF水平均非常显著地高于正常人组(P<0.01),经治疗后一个月,与正常人组比较仍有显著性差异(P<0.05)。结论:细胞因子IL-8、IL-10、IL-18和M-CSF在牙周病的发生、发展过程中相互作用,观察其浓度的变化对探讨其发病机理、预防和指导用药均有重要价值。
Objective To explore the significance of changes of serum IL- 8, IL- 10, IL- 18 and M -CSF levels in patients with periodontitis. Methods Serum levels of IL - 8, IL - 10, M - CSF （ with RIA） and IL - 18 （ with ELISA） were measured in 55 patients with periodontitis both before and after treatment as well as in 35 controls. Results Before treatment, serum levels of IL - 8, IL - 10, IL - 18 and M - CSF were significantly higher in the patients than those in the controls （ P 〈 0.01 ）. After one month of treat- ment, the serum IL -8, IL - 10, IL - 18 and M - CSF levels decreased somewhat, but were sdll significantly higher than those in con- trois （ P 〈 0.05）. CORCIUSiOR There was disturbance of immunomodulation in patients with periodontitis as expressed by the changes of several eytokines levels in the course of the diseases.
出处
《放射免疫学杂志》
CAS
2008年第2期119-121,共3页
Journal of Radioimmanology
关键词
牙周病
白细胞介素-8
白细胞介素-10
白细胞介素-18
巨噬细胞集落刺激因子
pefidontitis, interleukin - 8 （ IL - 8 ）, interleukin - 10 （ IL - 10）, interleukin - 18 （ IL - 18 ）, macrophage colony -stimulating factor （ M - CSF）
