摘要
目的探讨颈动脉粥样硬化患者的血管内皮功能。方法采用彩色多普勒超声对32例颈动脉粥样硬化患者和30名正常对照者肱动脉进行检测,观察反应性充血后和服用硝酸甘油后肱动脉内径的变化,并测定血脂水平。结果加压释放后颈动脉粥样硬化组肱动脉内径变化率显著低于对照组,含服硝酸甘油后肱动脉内径变化率也明显低于对照组,差异均有统计学意义(分别P<0.01和P<0.05)。血管内皮功能与总胆固醇(TC)、低密度脂蛋白(LDL-C)水平均成负相关关系(均P<0.01),与高密度脂蛋白(HDL-C)成正相关关系(P<0.05)。结论颈动脉粥样硬化患者既有血管内皮依赖性舒张功能障碍,又有血管非内皮依赖性舒张功能受损,超声是评价血管内皮功能简便可靠的方法。
Objective To study the vascular endothelial function in patients with atherosclerosis. Methods Thirtytwo patients with atherosclerosis and 30 age-matched normal controls were studied. Brachialartery diameter were measured with high-resolution ultrasound at rest, during reactive hyperemia and after sublingual nitroglycerin. The TC,TG,LDL-C, HDL-C were measured in all patients. Results The increased percentage of the brachialartery diameter was lower in patients comparing with those in the normal controls（P〈0.05）. The endothelial function correlated negatively with TC, LDL-C （r=-0.41 ,-0.66, P〈0.01）, positively with HDL-C （r=-0.62,P〈0.05）. Conclusion Vascular endothelial function was impaired in patients with atherosclerosis. It is an accurate and convenient method to evaluate the brachial arterial endothelial function with ultrasound.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2007年第6期922-923,共2页
Suzhou University Journal of Medical Science
